Words similar to tnf-alpha

Example sentences for: tnf-alpha

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However, as was the case with IL-1beta and TNF-alpha, PMA was not as effective as LPS in enhancing CEES toxicity.
LPS stimulation of macrophages is known to involve the activation of protein phosphorylation by kinases as well as the activation of nuclear transcription factors such as NF-kappaB [ 10 11 12 13 ] . The activation of protein kinase C (PKC) by diacylglycerol is also a key event in LPS macrophage activation [ 8 ] . In vitro experiments have shown that the secretion of TNF-alpha and IL-1-beta by LPS-stimulated monocytes is dependent upon PKC activation [ 13 14 ] . In this study, we also determined if phorbol myristate acetate (PMA) activation of PKC also enhanced CEES toxicity.
Inhibition of protein kinase C is known to block the secretion of TNF-alpha and IL-1beta [ 10 ] whereas stimulation of protein kinase C promotes TNF-alpha and IL-1beta production [ 22 ] . The data reported in Table 3show that stimulation of protein kinase C activity by PMA also enhances the cytotoxicity of CEES.
We have found that inflammatory agents such as LPS, TNF-alpha, IL-1beta, and PMA amplify the cytotoxicity of CEES to RAW264.
[ 14 ] have shown that TNF-alpha and IL-1beta secretion and mRNA accumulation by monocytes following LPS treatment is dependent on PKC activity.