Words similar to tnf-

Example sentences for: tnf-

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As an example, we assign a relative risk of 10 to the TNF-376A allele (this is the relative risk of the A allele compared to the G allele) and calculate the relative risks at all other SNPs in the TNF gene using the haplotype frequencies from The Gambia (Figure 5).
Most hypothetical disease SNPs in Malawi would be detectable by other SNPs in TNF, with the exception of TNF+476 and TNF-1073 which have very low frequency and little prospect of being detected by other markers.
The remaining eight SNPs in the TNF gene would have a relative risk between 0.8 and 0.9 when the relative risk at TNF-376A is 10 (Figure 4).
Interestingly, the TNF-863 SNP, of relatively high frequency in Malawi, shows no evidence of recombination with any other SNPs in the Malawian sample.
The next most common SNPs are the TNF+1304 (9%) and the TNF-863 (6%); however, the EMM does not choose these SNPs next because the TNF+1304 tends to occur in phase with the TNF+851, and the TNF-863 tends to occur in phase with the TNF-1031, both of which are already in the subset of four SNPs.