Example sentences for: tnf-induced

How can you use “tnf-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this study, using ribozyme technology, we demonstrate an association of decreased expression and function of the M6P/IGF2R with increased cell proliferation and decreased susceptibility to TNF-induced apoptosis in human breast cancer MCF-7 cells.

  • Fletcher et al [ 3 ] also reported that TNF-induced mortality could be reduced by using ibuprofen.

  • Preliminary studies on TNF-induced IκBα phosphorylation determined the optimum concentration for inhibition with infliximab.

  • Recent evidence suggests that lysosomal enzymes, such as cathepsins B and D contribute to TNF-induced apoptosis in vitro [ 35 36 37 38 ] and in vivo [ 39 ] . The M6P/IGF2 receptor has been shown to be involved in binding, transport and activation of lysosomal enzymes, including cathepsins [ 12 13 ] . Therefore, it is possible that down-regulation of the M6P/IGF2R results in improper trafficking and activation of cathepsins.

  • Our results also showed that M6P/IGF2R down-regulation resulted in decreased sensitivity of MCF-7 cells to TNF-induced apoptosis.


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