Words similar to tnf-mediated

Example sentences for: tnf-mediated

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TGF-β family proteins, including β1,β2 and β3, induce TNF-resistance and suppress the PH-20 effect of increasing TNF cytotoxicity in murine L929 fibroblasts [ 8 11 ] . TGF-β1 induces a novel extracellular matrix protein that prevents TNF-mediated cell death and blocks the activation of extracellular signal-regulated kinase (ERK; also known as p42/44 mitogen-activated protein kinase, p42/44 MAPK) in L929 cells [ 8 12 ] . Additionally, TGF-β1 induces the expression of TIAF1 (TGF-β-induced antiapoptotic factor) [ 13 ] and TIF2 (TGF-β-induced factor 2) [ 14 ] that inhibit TNF cytotoxicity.
It was determined that stable expression of murine Hyal-2 in L929 cells increased their sensitivity to TNF-mediated death, whereas Hyal-1 was somewhat less effective.
This reduction is probably due to TNF-mediated WOX1 nuclear translocation from the mitochondria [ 10 ] . In contrast, WOX1 was not expressed in L929 cells stably transfected with the GFP-Hyal-1 construct, and TNF induced WOX1 expression in 40 min (Fig.
Next, the effect of TNF-mediated IκBα degradation and NF-κB activation was examined in both Hyal-1 and Hyal-2 cells.
However, there was an extended period of TNF-mediated IκBα degradation and NF-κB activation in Hyal-2 cells, ranging from 20-60 min.