Words similar to tnf-α
Example sentences for: tnf-α
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Administration of IL-10 in vitro prevents TNF-α stimulated expression of MAdCAM-1, and also blocks lymphocyte adhesion to endothelial cells to the same extent as dexamethasone treatment, currently a key therapy in IBD [ 5 ] . Interestingly, the low basal levels of MAdCAM-1 expressed by control (cytokine unstimulated) cells were not affected by IL-10 transfection.
It was interesting that this motif was related to a sequence W x E xxxxx GG found at the C-terminal (amino acids 190-198) of TNF-α.
In summary, in our experiments the in vitro effect of a 1-6 hour exposure to domoic acid on rat neonatal microglia activation and concomitant TNF-α, MMP-9 and O 2 - release was clearly distinct in its magnitude from that observed after exposure to LPS, an agent involved in endotoxic shock and other central nervous pathologies [ 3 ] . Even though this present study was limited to the study of the in vitro effects of domoic acid on three microglia mediators, namely TNF-α, MMP-9 and O 2 -, it provides the first experimental evidence to our knowledge that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a limited activation of rat neonatal microglia and the concomitant release of modest though statistically significant amounts of TNF-α and MMP-9.
The results shown in Figure 6are expressed as pg/ml; IFN-γ(9 ± 2 vs 6 ± 1.6, p < 0.04), IL-4 (7 ± 0.35 vs 5.8 ± 0.36, p < 0.02) and IL-2 (7 ± 0.36 vs 6 ± 0.26 p < 0.03) without any change in the levels of TNF-α, IL-5 and IL-10.
In the HIV +cases also, the CD8 +T cells show significantly enhanced TNF-α production (2 fold).
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