Words similar to tnf-resistance
Example sentences for: tnf-resistance
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Testicular hyaluronidase PH-20 counteracts TGF-β1-induced TNF-resistance in L929 cells [ 8 ] . The goal of the present study was to examine whether lysosomal Hyal-1 and Hyal-2 enhance TNF cytotoxic function and counteract TGF-β1-mediated TNF-resistance in L929 cells.
TGF-β family proteins, including β1,β2 and β3, induce TNF-resistance and suppress the PH-20 effect of increasing TNF cytotoxicity in murine L929 fibroblasts [ 8 11 ] . TGF-β1 induces a novel extracellular matrix protein that prevents TNF-mediated cell death and blocks the activation of extracellular signal-regulated kinase (ERK; also known as p42/44 mitogen-activated protein kinase, p42/44 MAPK) in L929 cells [ 8 12 ] . Additionally, TGF-β1 induces the expression of TIAF1 (TGF-β-induced antiapoptotic factor) [ 13 ] and TIF2 (TGF-β-induced factor 2) [ 14 ] that inhibit TNF cytotoxicity.
In this study, experiments were designed to determine whether lysosomal Hyal-1 and Hyal-2 enhance TNF cytotoxic function and counteract TGF-β1-mediated TNF-resistance in L929 cells.
In contrast, TGF-β1 protects L929 cells from TNF cytotoxicity by upregulating the expression of antiapoptotic TIAF1, TIF2 and a novel matrix protein [ 11 12 13 14 ] . TGF-β1 blocks PH-20-increased TNF susceptibility [ 15 ] . Likewise, PH-20 inhibits TGF-β1-induced TNF-resistance [ 15 ] . TGF-β1 suppresses PH-20-mediated ERK activation [ 16 ] ; however, the ERK activation is not related with PH-20-increased TNF susceptibility in L929 cells [ 15 ] . Whether the proapoptotic p53 and WOX1 block the function of antiapoptotic TIAF1 and TIF2 is not known.
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