Words similar to tnf-ri
Example sentences for: tnf-ri
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TNF-RI is also a death receptor based on the presence of a carboxy-terminal functional domain known as the death domain.
Activation of TNF-RI and other death domain containing receptors of the TNF receptor superfamily have been shown to cause an efflux of GSH, which contributes to the apoptotic process [ 42 61 ] . Provision of GSH in the present study reduced the deleterious effects of TNFα on CLENDO cells.
Elevated TNFα activity may play a role in the apoptosis of CL-derived microvascular endothelial (CLENDO) cells [ 29 ] . TNFα is known to initiate apoptosis in diverse cell types by activating its cognate receptor, TNF-RI, a cell surface receptor and member of the tumor necrosis receptor super family (TNFRSF).
Alternatively, IFNγ may increase the expression of the death domain containing TNF-RI and thus increase the luteal endothelial cell death susceptibility upon exposure to TNFα.
One receptor for TNFα, TNF-RI is expressed throughout the bovine estrous cycle [ 46 ] , but is more abundantly expressed by the endothelial cell component than in steroidogenic cells [ 29 ] .