Words similar to proteoglycans
Example sentences for: proteoglycans
How can you use “proteoglycans” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cell-associated HS proteoglycans can undergo regulated shedding from the membrane into the soluble extracellular matrix or culturing medium converting the membrane anchored molecules into soluble effectors [ 1 2 ] . In the conditioned media of all the tested batches of retinoblastoma cells, we detected heparin and HS with binding affinity for PEDF.
Both cell adhesion and connective tissue remodeling are indispensable for normal development and maintenance of tissue integrity [ 13 14 15 ] . The differential expression of proteoglycans, collagens and cell adhesion molecules (for example cadherin 13) might be involved in genital morphogenesis and later stability of sexually dimorphic traits of the external genitalia.
The retina and malignant solid tumors also produce the sulfated GAGs [ 1 2 22 23 24 25 26 ] . Although HSs are mostly found as proteoglycans associated with the basal lamina or the plasma membrane, the presence of HSs in the culturing medium might be a result of shedding or release of their extracellular domains from the cell membranes as soluble components.
Aggrecan and versican are aggregating proteoglycans that are key constituents found in the extracellular matrix [ 41 ] . Both proteoglycans contain amino-terminal hyaluronic acid-binding regions, central core glycosaminoglycan attachment domains, and carboxyl-terminal domains containing EGF-like modules (one in aggrecan and two in versican), C-type lectin like modules and complement regulatory protein-like modules [ 49 50 ] . Fibulin-1 exhibits calcium-dependent binding to the carboxyl-terminal domain of aggrecan and versican [ 41 ] . The binding site of aggrecan to fibulin-1 maps to the type II EGF-like modules 8-9 and the carboxyl-terminal domain of fibulin-1 [ 41 ] . The binding site of versican to fibulin-1 maps to the type II EGF-like modules 2-8 of fibulin-1 [ 41 ] .
Alcian Blue (Sigma) was used to detect extracellular matrix proteoglycans in chondrogenic cultures.
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