Words similar to proteoglycan
Example sentences for: proteoglycan
How can you use “proteoglycan” in a sentence? Here are some example sentences to help you improve your vocabulary:
T-cell proliferation was assessed on day 5 by [ 3H]thymidine incorporation [ 14 22 ] . Antigen (proteoglycan)-specific interferon-γ, IL-10, and IL-4 production by T cells was determined in media collected on day 4 using capture enzyme-linked immunosorbent assays (ELISAs) from BioSource International, Inc. (Camarillo, CA, USA).
To exclude the possibility that different CD4 +CD25 +-expressing T cells may be a strain- and/or antigen-dependent phenomenon, we immunized BALB/c mice (PGIA-susceptible strain) and C57BL/6 (arthritis-resistant strain) with human cartilage proteoglycan or ovalbumin.
However, CD28-deficient T cells from proteoglycan-immunized animals can proliferate in response to proteoglycan stimulation in vitro , albeit at a rate lower than that in wild-type T cells, which is consistent with the report by Oliveira-dos-Santos et al . [ 30 ] . It has been demonstrated that, in the absence of CD28 engagement, T cells require very high TCR occupancy and prolonged stimulation, whereas CD28 costimulation allows T cells to respond to lower degrees of TCR occupancy [ 30 31 ] . In support of this observation, CD28 -/-mice can still mount immune responses, which vary in magnitude and efficiency depending on the antigen or infectious agent [ 30 32 ] . Our results and those reported by others [ 30 ] suggest that CD28 may regulate the threshold for T-cell activation.
3a,3b), and the disease continued to progress in saline-treated mice at 6 weeks, with increased cell proliferation and inflammatory cell infiltration, erosion of cartilage and bone, and loss of proteoglycan from the cartilage (Fig.
Purified CD4 +CD25 +regulatory T cells (3-20 × 10 5) from naïve BALB/c mice, together with 10 7spleen cells from arthritic mice that were depleted of CD25 +T cells and 100 μg proteoglycan, were injected intraperitoneally into SCID mice [ 18 ] , and the incidence and severity of disease were monitored.
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