Words similar to proteoglycan

Example sentences for: proteoglycan

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BALB/c mice immunized with human cartilage proteoglycan (PG) (aggrecan) develop arthritis [ 1, 2, 3, 4].
To determine whether overexpression of TGF-β1 had effects on cartilage metabolism in naïve and AIA rabbit joints, GAG synthesis by articular cartilage and GAGs released into synovial fluid as a result of proteoglycan breakdown were measured.
The proteoglycan content of the cartilage was notably improved.
However, CD28-deficient T cells from proteoglycan-immunized animals can proliferate in response to proteoglycan stimulation in vitro , albeit at a rate lower than that in wild-type T cells, which is consistent with the report by Oliveira-dos-Santos et al . [ 30 ] . It has been demonstrated that, in the absence of CD28 engagement, T cells require very high TCR occupancy and prolonged stimulation, whereas CD28 costimulation allows T cells to respond to lower degrees of TCR occupancy [ 30 31 ] . In support of this observation, CD28 -/-mice can still mount immune responses, which vary in magnitude and efficiency depending on the antigen or infectious agent [ 30 32 ] . Our results and those reported by others [ 30 ] suggest that CD28 may regulate the threshold for T-cell activation.
Among the genes most highly correlated with IL-8 in tumor tissues are KLF2, PS1, VEGF, and tumor necrosis factor receptor-1 (TNFR-1), lumican (keratin sulfate proteoglycan), claudin-3, and perlecan.