Words similar to proteoglycan-induced
Example sentences for: proteoglycan-induced
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Proteoglycan-induced arthritis (PGIA) is a novel autoimmune murine model that is induced by systemic immunization of BALB/c mice with cartilage proteoglycans [ 12 13 ] . The development of PGIA is based on the cross-reactive immune response between immunizing human and mouse (self) cartilage proteoglycans in genetically susceptible BALB/c mice [ 12 13 ] . Several lines of evidence indicate T-cell involvement in the pathogenesis of PGIA.
Interestingly, proteoglycan-induced proliferation of CD4 +CD25 -T cells could not be inhibited by the CD4 +CD25 +T cells (Fig.
AICD = activation-induced cell death; CTLA = cytotoxic T-lymphocyte antigen; ELISA = enzyme-linked immunosorbent assay; FITC = fluorescein isothiocyanate; IL = interleukin; PE = R-phycoerythrin; PG = proteoglycan; PGIA, proteoglycan-induced arthritis; SCID = severe combined immunodeficient; TCR = T-cell receptor; TGF = transforming growth factor; WT = wild-type.
Treatment with recombinant IL-10 in CIA, in proteoglycan-induced arthritis, and in experimental autoimmune encephalomyelitis reduced disease severity, and neutralizing IL-10 with antibodies exacerbated disease [ 19 20 22 23 ] . The present data are consistent with previous results and show that a complete absence of IL-10 exacerbates inflammation in CIA [ 37 38 39 ] . The anti-inflammatory properties of IL-10 suggest that endogenous IL-10 may function as a regulator of proinflammatory mediators in vivo [ 39 ] . It is interesting, however, that disease severity inversely correlates with the levels of IFN-γ in IL-10 -/-mice, suggesting that IL-10 may control disease activity via regulating IFN-γ responses.
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