Words similar to proteoglycan-specific

Example sentences for: proteoglycan-specific

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1 μg protein/100 μl per well) for ELISA, and free binding capacity of the wells was blocked by 1% fat-free milk in phosphate-buffered saline [ 23 24 25 ] . Sera were applied at increasing dilutions and isotypes of proteoglycan-specific antibodies were determined using peroxidase-conjugated rat antimouse IgG 1 or IgG 2a secondary antibodies (Zymed, South San Francisco, CA, USA) as previously described [ 24 26 ] . Serum antibody levels were calculated according to mouse IgG 1 and IgG 2a standards.
First, CD4 +T cells selectively proliferate in response to proteoglycan antigens [ 14 ] . Second, prevention of arthritis can be achieved by in vivo treatment with anti-CD4 monoclonal antibodies [ 15 ] . Third, arthritis can be transferred to naïve BALB/c or severe combined immunodeficient (SCID) mice using T and B cells from arthritic animals [ 16 17 18 ] . Fourth, a proteoglycan-specific T-cell hybridoma (T-helper-1 type) can induce arthritis in BALB/c mice [ 19 ] . Finally, CD4 +T cells from arthritic animals are resistant to activation-induced cell death [ 20 ] . These data suggest a breakdown of peripheral tolerance and accumulation of autoreactive T cells in the periphery.
Proteoglycan-specific T-cell proliferation and production of IL-4, interferon-γ, IL-10, TGF-β 1 and antiproteoglycan autoantibodies were comparable in both transfer groups (Fig.