Words similar to phentermine
Example sentences for: phentermine
How can you use “phentermine” in a sentence? Here are some example sentences to help you improve your vocabulary:
Doctors reported that fenfluramine and phentermine, a popular diet pill combination, may cause severe heart-valve disease . The story is all over front pages and the TV news because the pills are prescribed about 20 million times a year.
Since the initial report by Connolly, et al [ 1 ] of valvulopathy in women taking the combination of fenfluramine and phentermine (fen-phen), controversy has surrounded the issue of associated risk.
We first evaluated studies reporting echocardiographic prevalence of FDA-positive valvulopathy (mild or greater AR and moderate or greater MR) [ 2 ] among subjects who had taken either fenfluramine or dexfenfluramine (alone or in combination with phentermine) and in matched controls [ 7 8 9 10 11 12 13 14 ] . In most of these studies, echocardiograms were performed after the drugs had been discontinued and were read without knowledge of prior drug exposure by multiple readers (table 1).
Some recent reviews conclude that the risks associated with fenfluramine and dexfenfluramine are similar, real but modest for aortic valve disease, and barely detectable for mitral valve disease; phentermine appears not to be associated with increased risk [ 17 18 19 20 ] . Nevertheless, interpretation of the results of these studies has been so varied that some authors have even questioned any causal relationship for fenfluramine exposure [ 21 ] . However, analyses to date have not formally considered major biases that would act to deflate the actual risk associated with fenfluramine use.
Initial reports of remarkably high prevalence of aortic and mitral regurgitation (AR and MR) as assessed by echocardiography in five separate populations [ 2 ] were subsequently supported by most [ 3 4 5 ] but not all investigators [ 6 ] . These uncontrolled reports were soon followed by a series of studies in which prevalence of echocardiographically-defined AR and MR were assessed in persons who had taken fenfluramine, dexfenfluramine, phentermine, or combinations of these medications and compared to unexposed, matched control populations [ 7 8 9 10 11 12 13 14 15 ] . The most recent of these studies found 30% of persons currently taking fenfluramine or dexfenfluramine had mild or greater AR or moderate or greater MR, similar to the very high prevalence reported in older studies [ 15 ] . The only prospective study found a significant, exposure-related increase in the risk of clinically diagnosed valve disease among users of fenfluramine and dexfenfluramine, but not phentermine [ 16 ] .
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