Example sentences for: osteoclasts

How can you use “osteoclasts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Its principal function appears to be the conservation of body calcium stores in certain physiologic states such as growth, pregnancy and lactation, and the maintenance of bone mineral in emergency situations by means of attenuation of the activity of osteoclasts [ 14].

  • A dose of 200 ng/ml RANKL generated numerous large, multinucleated osteoclasts.

  • Once in the tissue, monocytes undergo the poorly understood process of transformation to macrophages with altered morphology and function [ 19 ] . In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20 ] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8 ] . It has therefore been suggested that therapies for chronic arthritis should be aimed at depleting joint mononuclear cells or controlling the activation of synovial macrophages [ 21 ] . Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22 ] and antigen-induced arthritis [ 23 ] induces amelioration of the arthritis.

  • Cells thus obtained were observed in time-lapse cinematography, assayed for proliferation, and examined immunohistologically and histochemically, and their ability to become fibroblasts, osteoclasts, osteoblasts, and adipocytes was documented.

  • Maturation of osteoclasts from their macrophage precursors requires marrow stromal cells or their osteoblast progeny as shown by Udagawa et al [ 23].


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