Example sentences for: osteoclasts

How can you use “osteoclasts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Pretreatment of RAW cells with RANKL for 48 hours rendered them resistant to IFN-γ; these mononuclear cells formed multinuclear osteoclasts despite the presence of maximally inhibitory doses of IFN-γ (10 ng/ml).

  • Estradiol has been shown to modulate IL-1 action on human osteoclasts in vitro; estrogen administration inhibited IL-1-mediated cytokine (IL-8) mRNA induction and caused increased Ocl apoptosis [ 26].

  • Osteoclasts were counted using three equivalent methods, optimized for the extent of osteoclastogenesis.

  • The present results suggest that the influence of activated T cells on osteoclasts will probably change depending on when and where the T cells encounter the osteoclasts.

  • Once in the tissue, monocytes undergo the poorly understood process of transformation to macrophages with altered morphology and function [ 19 ] . In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20 ] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8 ] . It has therefore been suggested that therapies for chronic arthritis should be aimed at depleting joint mononuclear cells or controlling the activation of synovial macrophages [ 21 ] . Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22 ] and antigen-induced arthritis [ 23 ] induces amelioration of the arthritis.


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