Example sentences for: osteoclastogenic

How can you use “osteoclastogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In the case of circulating or peripheral macrophages that have not encountered osteoclastogenic quantities of RANKL, IFN-γ rapidly induces macrophage activation and subsequent NO production, recruiting these cells for immune responses.

  • Based on the phenotype of knockout mice, it has become clear that TRAF6 is the critical adapter molecule required for RANK signaling during osteoclastogenesis [ 35 ] . The importance of TRAF6 has been further explored in deletion studies, which correlated its various domains with its osteoclastogenic potential [ 46 ] . A link between IFN-γ and RANK signaling via TRAF6 has also been demonstrated in bone marrow cultures, in which IFN-γ was shown to accelerate the degradation of TRAF6 [ 38 ] . In our studies, however, we failed to observe this TRAF6 degradation, as its expression remained constant in both short-term and long-term cultures under conditions where IFN-γ completely inhibited osteoclastogenesis.


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