Example sentences for: osteoclastogenesis

How can you use “osteoclastogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These data may help explain the contradictory findings regarding the effects of IFN-γ as an inhibitor of osteoclastogenesis, and also suggest a model of erosive disease in the presence of IFN-γ whereby osteoclast precursors are exposed to RANKL before they enter the IFN-γ-rich environment.

  • Osteoblasts are also known to secrete osteoprotegerin (OPG), which binds TRANCE, thus inhibiting osteoclastogenesis.

  • To evaluate the effects of IFN-γ on osteoclastogenesis, we utilized the mouse macrophage cell line RAW264.

  • The proinflammatory cytokines tumor necrosis factor alpha, IL-1, and IL-6 augment osteoclastogenesis [ 9 10 11 ] , while IL-10, IL-12, IL-18, and IFN-γ antagonize osteoclastogenesis in vitro [ 12 13 14 15 ] . It is probable that cytokines play a vital role in the delicate balance of bone remodeling, and that therapies based upon their natural biological function can be designed.

  • Development of osteosclerosis and the disappearance of the marrow space in these estrogen-treated mice is an interesting and useful model since marrow stromal cells not only contain the precursors for osteogenic cell lineages, but they also exert important effects on osteoclastogenesis and lymphopoiesis, and modulate the effects of some systemic factors of bone turnover.


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