Words similar to osteoclastogenesis
Example sentences for: osteoclastogenesis
How can you use “osteoclastogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:
For cultures utilizing lower levels of RANKL and low osteoclast numbers, densitometric quantitation of TRAP was a more sensitive measure of osteoclastogenesis (Fig.
Development of osteosclerosis and the disappearance of the marrow space in these estrogen-treated mice is an interesting and useful model since marrow stromal cells not only contain the precursors for osteogenic cell lineages, but they also exert important effects on osteoclastogenesis and lymphopoiesis, and modulate the effects of some systemic factors of bone turnover.
While IFN-γ is not highly expressed in joints of patients with rheumatoid arthritis, diseases such as erosive tuberculoid leprosy [ 23 24 ] and psoriatic arthritis [ 25 ] are associated with high Th1 cytokines such as IFN-γ [ 26 ] . In these conditions, tissue destruction has been shown to correlate with Th1-mediated immune responses and the production of IFN-γ, indicating that osteoclastogenesis may occur in the presence of elevated IFN-γ [ 27 ] .
With respect to osteoclast formation, IFN-γ is known to potently inhibit RANKL-mediated osteoclastogenesis in both spleen-derived macrophage cultures and bone marrow coculture systems [ 19 20 21 ] . It has also been demonstrated that mice defective in IFN-γ signaling have a more rapid onset of arthritis and bone resorption compared with wild-type mice, suggesting a protective role of IFN-γ in early arthritis [ 21 22 ] .
Based on the phenotype of knockout mice, it has become clear that TRAF6 is the critical adapter molecule required for RANK signaling during osteoclastogenesis [ 35 ] . The importance of TRAF6 has been further explored in deletion studies, which correlated its various domains with its osteoclastogenic potential [ 46 ] . A link between IFN-γ and RANK signaling via TRAF6 has also been demonstrated in bone marrow cultures, in which IFN-γ was shown to accelerate the degradation of TRAF6 [ 38 ] . In our studies, however, we failed to observe this TRAF6 degradation, as its expression remained constant in both short-term and long-term cultures under conditions where IFN-γ completely inhibited osteoclastogenesis.
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