Words similar to osteoclastogenesis
Example sentences for: osteoclastogenesis
How can you use “osteoclastogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:
The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .
While IFN-γ is not highly expressed in joints of patients with rheumatoid arthritis, diseases such as erosive tuberculoid leprosy [ 23 24 ] and psoriatic arthritis [ 25 ] are associated with high Th1 cytokines such as IFN-γ [ 26 ] . In these conditions, tissue destruction has been shown to correlate with Th1-mediated immune responses and the production of IFN-γ, indicating that osteoclastogenesis may occur in the presence of elevated IFN-γ [ 27 ] .
The different kinetics between IFN-γ-mediated macrophage activation (<24 hours) and RANKL-medicated osteoclastogenesis (4-5 days) prompted us to investigate the effects of IFN-γ on RANKL-pretreated cells (Fig.
To evaluate the effects of IFN-γ on osteoclastogenesis, we utilized the mouse macrophage cell line RAW264.
Hofbauer et al suggest that the stimulation of the pool of M-CSF precursors to committed osteoclastogenesis by RANKL may be one of the central pathophysiologic pathways involved in increasing the number of osteoclasts in osteoporosis.
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