Words similar to osteoclastogenesis
Example sentences for: osteoclastogenesis
How can you use “osteoclastogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:
Futures studies of the estrogen-treated mouse model are needed which are designed to address osteoclastogenesis and osteoprotegerin (OPG) secretion by osteoblasts.
The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .
IFN-γ potently and irreversibly inhibits RANKL-induced osteoclastogenesis
The bioactivity of GST-RANKL was verified by RAW cell osteoclastogenesis and TRAP expression before experimental use.
The molecular signals required for osteoclastogenesis have recently been elucidated [ 1 4 5 ] . Receptor-activator of NFκB ligand (RANKL), a tumor necrosis factor superfamily ligand expressed by stromal cells, osteoblasts, and activated T cells, binds to its cognate receptor-activator of NFκB (RANK) receptor on macrophages/monocytes, inducing a signal that gradually transforms the macrophages into osteoclasts over a period of several days [ 6 7 ] . While this interaction occurs largely in the bone microenvironment, it has been shown that monocytes from the spleen, peripheral blood, and synovium are all capable of RANKL-dependent osteoclast formation [ 8 ] . Convincing evidence has been generated indicating that the RANK-RANKL interaction is absolutely required for osteoclastogenesis [ 7 ] ; in the absence of these molecules, osteoclastogenesis cannot occur [ 9 ] .
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