Example sentences for: osteoclastogenesis

How can you use “osteoclastogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For cultures utilizing lower levels of RANKL and low osteoclast numbers, densitometric quantitation of TRAP was a more sensitive measure of osteoclastogenesis (Fig.

  • The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .

  • Hofbauer et al suggest that the stimulation of the pool of M-CSF precursors to committed osteoclastogenesis by RANKL may be one of the central pathophysiologic pathways involved in increasing the number of osteoclasts in osteoporosis.

  • Osteoclasts were counted using three equivalent methods, optimized for the extent of osteoclastogenesis.

  • In the present study, we demonstrate that early exposure to RANKL renders osteoclast precursors resistant to the effects of IFN-γ, including inhibition of osteoclastogenesis.


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