Words similar to osteoarthritis
Example sentences for: osteoarthritis
How can you use “osteoarthritis” in a sentence? Here are some example sentences to help you improve your vocabulary:
AP-1 = activator protein-1; COL2A1 = procollagen 2 alpha 1; egr-1 = early growth response gene-1; ets = erythroblastosis gene twenty-six; IL-1β = interleukin-1β; LH = lactalbumin hydrolysate; LIF = leukemia inhibitory factor; MAPK= mitogen-activated protein kinase; MMP = matrix metalloproteinase; NF-κB = nuclear factor-κB; OA = osteoarthritis; PDGF = platelet-derived growth factor; RT-PCR = reverse transcriptase polymerase chain reaction; SMAD4 = mothers against dpp homolog 4; TGF-β = transforming growth factor-β.
As a novel approach to therapy, we and other workers have focused on developing the methods for local transfer of genes encoding therapeutic agents to the joint [ 13 14 15 16 17 18 19 ] . This strategy also can be applied to the treatment of osteoarthritis and for aiding the repair of the cartilage and other intra-articular tissues.
Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .
CDDO = 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; DMEM = Dulbecco's modified Eagle's medium; GAPDH = glyceraldehyde-3-phosphate dehydrogenase; IκB = inhibitor of NF-κB; IL = interleukin; MMP = matrix metalloproteinase; OA = osteoarthritis; RA = rheumatoid arthritis; RT-PCR = reverse-transcriptase polymerase chain reaction; TNF-α = tumor necrosis factor-α.
Ang = angiopoietin; BSA = bovine serum albumin; FBS = fetal bovine serum; HMVEC = human microvascular endothelial cell; OA= osteoarthritis; PCR = polymerase chain reaction; RA = rheumatoid arthritis; RT-PCR = reverse transcription polymerase chain reaction, SE = standard error; Tie = receptor tyrosine kinase; VEGF = vascular endothelial growth factor.
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