Example sentences for: osteoarthritis

How can you use “osteoarthritis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Gene therapy represents a novel approach for delivery of therapeutic agents to joints in order to treat the pathologies associated with RA and osteoarthritis, as well as other disorders of the joints.

  • IL-1 has been implicated as a pathogenic mediator in numerous inflammatory and degenerative conditions, including rheumatoid arthritis (RA) and osteoarthritis (OA) [ 1 ] . The IL-1 receptor antagonist (IL-1Ra), a naturally occurring inhibitor of the biologic actions of IL-1, has obvious therapeutic potential in such diseases [ 2 ] ; indeed recombinant human IL-1Ra (anakinra) has recently been approved for use in patients with RA as the drug Kineret™ (Amgen, Inc., Thousand Oaks, CA, USA).

  • Since TGF-β1 has anti-inflammatory properties as well as being able to stimulate new matrix synthesis by chondrocytes, it represents a possible therapeutic agent with which to treat pathologies associated with rheumatoid arthritis and osteoarthritis by local gene delivery.

  • 9 kg/m 2and obese if it was ≥ 30 kg/m 2. Additional BMI data required for comparison purposes were obtained from currently available population-based estimates of BMIs in the American adult population [ 8, 9, 10] and from 110 age-matched patients of both genders without symptomatic hip osteoarthritis who were hospitalized concurrently.

  • Recent work by Hasty and coworkers [ 3] has demonstrated that local expression of IL-1β by articular chondrocytes activates autocrine gene expression, which contributes to the pathogenesis of osteoarthritis (OA).


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