Example sentences for: osteoarthritis

How can you use “osteoarthritis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Gene therapy represents a novel approach for delivery of therapeutic agents to joints in order to treat the pathologies associated with RA and osteoarthritis, as well as other disorders of the joints.

  • Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .

  • DMEM = Dulbecco's modified Eagle medium; ELISA = enzyme-linked immunosorbent assay; FBS = fetal bovine serum; HSF = human synovial fibroblast; (r/t)IL-1Ra = (recombinant/transgenic) IL-1 receptor antagonist; OA = osteoarthritis; PBS = phosphate-buffered saline; PGE 2 = prostaglandin E 2 ; RA = rheumatoid arthritis.

  • ELISA = enzyme-linked immunosorbent assay; IP-10 = interferon-gamma inducible protein 10; mAb = monoclonal antibody; MCP-1 = monocytechemotactic protein-1; MIP = macrophage inflammatory protein; OA = osteoarthritis; PBMC = peripheral blood mononuclear cells; PE = phycoerythrin;RA = rheumatoid arthritis; RANTES = regulated upon activation, normal T cell expressed and secreted; RT-PCR = reverse transcriptase-polymerasechain reaction; SCL = stromal cell line; SRBC = sheep red blood cells; TNF-α = tumor necrosis factor-α.

  • RA SCL, osteoarthritis (OA) SCL, and skin fibroblasts (1 × 10 5) were seeded in six-well culture plates (Costar) with DMEM containing 10% FBS, 200 U/ml penicillinG, 10 μg/ml gentamicin and 0.3 mg/ml L-glutamine, and cultured for 3 days.

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