Example sentences for: osteoblast

How can you use “osteoblast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Normal osteoblast cell cultures were prepared from mouse neonates according to a method previously described for chicken embryos [ 59 ] . Bone-forming cells were isolated from mouse neonate calvariae by sequential collagenase and protease digestions.

  • Statins, potent compounds that inhibit cholesterol synthesis in the liver by blocking 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), have been reported to induce osteoblast activity and lead to bone formation, both in tissue culture and in rats and mice [ 1 2 3 4 5 6 ] . These findings, if confirmed and extended to include humans, have the potential to introduce immediate new treatment options to patients with low bone mass and osteoporosis.

  • They proliferated rapidly in culture, had an adherent, spread morphology, displayed cytoskeletal, cytoplasmic, and surface markers of mesenchymal precursors, and had a capacity for differentiation into fibroblast, osteoblast, and adipocyte lineages.

  • The digestion step was repeated twice, and the 3 cell isolates were pooled in mouse osteoblast growth medium (OBGM), consisting of Dulbecco's modified Eagle's medium containing 25 mM HEPES, 10% fetal bovine serum (Sigma), 2 g of sodium bicarbonate per liter, 75 μg of glycine/ml, 100 μg of ascorbic acid/ml, 40 ng of vitamin B 12 /ml, 2 μg of p -aminobenzoic acid/ml, 200 ng of biotin/ml, and penicillin (100 U/ml)-streptomycin (100 μg/ml)-amphotericin B (25 μg/ml) (pH 7.4) [ 60 ] . Cells were seeded in six-well cluster plates and incubated at 37°C in a 5% CO 2 atmosphere until they reached confluence (6 to 7 days).

  • The highest concentration of antibodies used significantly reduced the level of caspase-8 activation in S. aureus -infected osteoblast cultures (p < 0.05).


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