Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • M-CSF is essential for macrophage maturation, but formation of osteoclasts also requires contact between osteoclast precursors and stromal cells or osteoblasts [ 23].

  • Proper sealing of the osteoclast against the bone surface and a functional brush border are two ultrastructural components believed to be of major importance in Ocl function.

  • For cultures utilizing lower levels of RANKL and low osteoclast numbers, densitometric quantitation of TRAP was a more sensitive measure of osteoclastogenesis (Fig.

  • These effects were irreversible and not caused by inhibition of proximal signaling at the level of STAT1 or TRAF6, suggesting that resistance to IFN-γ is caused by a complex differentiation program specifying the osteoclast fate.

  • The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .


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