Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Using this technique, we analyzed cytokine (IL-2, IL-4, IL-6, IL-10, IL-13, IFN-γ, TNF-α, and LT-α), activation marker (CD154 [CD40 ligand] and TRANCE - also called receptor activator of nuclear factor-κ B ligand [RANKL] or osteoclast differentiation factor [ODF]), and chemokine receptor expression by individual CD4 +memory T cells isolated from rheumatoid synovium and blood.

  • 7 (RAW cells) or splenic macrophages from CBA/BL6 mice as osteoclast precursors.

  • In the present study in the mouse, differentiation of osteoclast progenitors appears to be dependent on the direct interaction of bone marrow stromal cells with Ocl precursor cells [ 19, 20].

  • M-CSF is essential for macrophage maturation, but formation of osteoclasts also requires contact between osteoclast precursors and stromal cells or osteoblasts [ 23].

  • The dominance of IFN-γ over RANKL, which we observed in vitro (1 ng IFN-γ counteracts 200 ng RANKL when simultaneously administered), probably allows this macrophage activation to occur even in the presence of RANKL expressed on circulating, activated T cells [ 20 40 ] . In the bone microenvironment, however, more abundant RANKL produced by osteoblasts/stromal cells may influence certain monocytes to commit to the osteoclast lineage [ 41 42 ] .


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