Words similar to osteoclast
Example sentences for: osteoclast
How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:
Human RANKL was a gift from Immunex (Seattle, USA) and was used to verify the efficiency of GST-RANKL protein as verified by splenic osteoclast induction.
In the present study we analyzed cytokine (IL-2, IL-4, IL-6, IL-10, IL-13, IFN-γ , TNF-α , and LT-α ), activation marker (CD154 [CD40 ligand] and TRANCE - also called receptor activator of nuclear factor κ B ligand [RANKL] or osteoclast differentiation factor [ODF]), and chemokine receptor expression by individual CD4 +memory T cells isolated from rheumatoid synovium and blood.
The CD98 (4F2, FRP-1) molecule, a cell surface disulfide-linked heterodimer, was originally described as a T cell activation antigen [ 1 ] , and later was shown to provide a co-stimulatory signal for CD3-mediated T-cell activation [ 2 ] , independent of CD28/CD80/CD86 interaction [ 3 ] . In other studies, triggering of human monocyte CD98 could suppress T cell proliferation [ 4 ] , or promote homotypic cell aggregation of monocytes [ 5 ] . Also, CD98 may be a target antigen for natural killer cells [ 6 ] , may mediate fusion of blood monocytes leading to osteoclast formation [ 7 8 ] , and may modulate hematopoietic cell survival and differentiation [ 9 ] .
M-CSF is essential for macrophage maturation, but formation of osteoclasts also requires contact between osteoclast precursors and stromal cells or osteoblasts [ 23].
Considering the tremendous morbidity and cost of metabolic bone diseases [ 3 ] , improving our molecular understanding of osteoclast development and function is critical towards the design of therapies to combat these prevalent diseases.
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