Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • With respect to osteoclast formation, IFN-γ is known to potently inhibit RANKL-mediated osteoclastogenesis in both spleen-derived macrophage cultures and bone marrow coculture systems [ 19 20 21 ] . It has also been demonstrated that mice defective in IFN-γ signaling have a more rapid onset of arthritis and bone resorption compared with wild-type mice, suggesting a protective role of IFN-γ in early arthritis [ 21 22 ] .

  • The rapid and irreversible effects of IFN-γ on osteoclast inhibition indicate a dominant effect of this cytokine over RANKL via induction of monocyte differentiation toward the activated macrophage fate, as opposed to the osteoclast fate, when concomitantly administered.

  • These included the obvious - MCAM (melanoma cell adhesion molecule) - but also ATP1B2 (ATPase, Na +/K +transporting, beta 2 polypeptide, which is believed to function in neuron-astrocyte adhesion [ 29, 30]), THBS (thrombospondin, an adhesion molecule involved in blood clotting), OPN (osteopontin, which promotes osteoclast adhesion [ 31]) and OSF2 (osteoblast-specific factor 2, a human homolog of the insect protein fasciclin thought to have a role in bone adhesion [ 32]).

  • Human RANKL was a gift from Immunex (Seattle, USA) and was used to verify the efficiency of GST-RANKL protein as verified by splenic osteoclast induction.

  • in rats, where the anabolic effect of lovastatin on bone was at least partially due to their inhibiting effect on osteoclast development [ 28 ] . Similarly, in the mouse calvaria model Gasser et al.


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