Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These data support the hypothesis that sensitivity to IFN-γ decreases with increasing osteoclast differentiation and that the mechanism by which RANKL and IFN-γ reciprocally inhibit each other in pre-osteoclasts is mediating the irreversible commitment into the osteoclast or activated macrophage lineages.

  • These effects were irreversible and not caused by inhibition of proximal signaling at the level of STAT1 or TRAF6, suggesting that resistance to IFN-γ is caused by a complex differentiation program specifying the osteoclast fate.

  • We have demonstrated, using in vitro methods, that osteoclast precursors exposed to RANKL for 1-2 days can be rendered resistant to maximal osteoclast-inhibitory doses of IFN-γ.

  • Although the role of the osteoclast in bone resorption is becoming better understood [ 1], much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents on the functional osteoclast.

  • Hematopoietic cells also influence osteogenic cell differentiation, and some evidence suggests that mature lymphocytes influence osteoclast and osteoblast function.


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