Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Findings extend our understanding of osteoclast structure and function in the mouse exposed in vivo to high doses of estrogen.

  • For cultures utilizing lower levels of RANKL and low osteoclast numbers, densitometric quantitation of TRAP was a more sensitive measure of osteoclastogenesis (Fig.

  • Although the role of the osteoclast in bone resorption is becoming better understood [ 1], much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents on the functional osteoclast.

  • The dominance of IFN-γ over RANKL, which we observed in vitro (1 ng IFN-γ counteracts 200 ng RANKL when simultaneously administered), probably allows this macrophage activation to occur even in the presence of RANKL expressed on circulating, activated T cells [ 20 40 ] . In the bone microenvironment, however, more abundant RANKL produced by osteoblasts/stromal cells may influence certain monocytes to commit to the osteoclast lineage [ 41 42 ] .

  • The strength of the early RANKL signal may be altered in the setting of inflammatory bone diseases such as rheumatoid arthritis, in which high levels of RANKL expressed on either synovial cells or infiltrating T cells [ 43 44 ] may induce osteoclast formation despite the presence of exogenous or endogenous IFN-γ.


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