Words similar to osteoclast

Example sentences for: osteoclast

How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:

Osteoblasts are known to secrete tumor necrosis factor-related activation-induced cytokine (TRANCE) (RANK-L), which acts on the TRANCE receptor (TRANCE-R) (RANK) found on osteoclast precursors.
The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .
We next investigated whether other IFN-γ effects besides osteoclast inhibition were blunted in RANKL-pretreated cells.
Girasole et al have recently shown that production of IL-6 is inhibited in vitro by exposure of marrow cells to 17β-estradiol; cultures of mouse bone cells showed suppressed osteoclast development when exposed to either 17β-estradiol or a neutralizing antibody to Il-6 [ 31].
In the present study in the mouse, differentiation of osteoclast progenitors appears to be dependent on the direct interaction of bone marrow stromal cells with Ocl precursor cells [ 19, 20].