Words similar to osteoclast
Example sentences for: osteoclast
How can you use “osteoclast” in a sentence? Here are some example sentences to help you improve your vocabulary:
The rapid and irreversible effects of IFN-γ on osteoclast inhibition indicate a dominant effect of this cytokine over RANKL via induction of monocyte differentiation toward the activated macrophage fate, as opposed to the osteoclast fate, when concomitantly administered.
7 (RAW cells) or splenic macrophages from CBA/BL6 mice as osteoclast precursors.
Osteoblasts are known to secrete tumor necrosis factor-related activation-induced cytokine (TRANCE) (RANK-L), which acts on the TRANCE receptor (TRANCE-R) (RANK) found on osteoclast precursors.
In contrast, Wei et al . have demonstrated that pre-osteoclasts do not lose their potential to differentiate into mature osteoclasts following a similar exposure to IL-4 [ 50 ] . It thus appears that IFN-γ anti-osteoclast activity is mediated by inducing terminal differentiation away from the osteoclast lineage, while IL-4 directly interferes with RANKL signaling during osteoclastogenesis.
The CD98 (4F2, FRP-1) molecule, a cell surface disulfide-linked heterodimer, was originally described as a T cell activation antigen [ 1 ] , and later was shown to provide a co-stimulatory signal for CD3-mediated T-cell activation [ 2 ] , independent of CD28/CD80/CD86 interaction [ 3 ] . In other studies, triggering of human monocyte CD98 could suppress T cell proliferation [ 4 ] , or promote homotypic cell aggregation of monocytes [ 5 ] . Also, CD98 may be a target antigen for natural killer cells [ 6 ] , may mediate fusion of blood monocytes leading to osteoclast formation [ 7 8 ] , and may modulate hematopoietic cell survival and differentiation [ 9 ] .
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