Words similar to osteoblasts

Example sentences for: osteoblasts

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Alternatively, intracellular bacteria may be the only S. aureus cells capable of inducing TRAIL expression by osteoblasts.
We have previously demonstrated that S. aureus induces TRAIL expression in normal human and mouse osteoblasts [ 41 ] . Messenger RNA encoding TRAIL is rapidly and dramatically up-regulated following exposure of osteoblasts to S. aureus . TRAIL mRNA expression is absent in uninfected cultures and shows a dose-dependent response to S. aureus . In contrast to the inducible nature of TRAIL mRNA, the messages encoding death-domain-containing TRAIL receptors are constitutively expressed in human and mouse osteoblasts [ 41 ] . Additionally, TRAIL protein is expressed and secreted following infection of osteoblasts with S. aureus . In contrast, uninfected osteoblasts do not express significant amounts of TRAIL protein.
S. aureus at a MOI of 25:1, 75:1, or 250:1 was unable to induce TRAIL expression when direct contact between bacteria and osteoblasts was precluded.
Therefore, the ability of TRAIL expressed by S. aureus -infected osteoblasts to mediate osteoblast apoptosis was examined.
Direct physical contact between S. aureus and osteoblasts at a MOI of 250:1 induced osteoblast TRAIL protein expression (Fig.