Words similar to osteoarthritis-like

Example sentences for: osteoarthritis-like

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The notion that the differential ability to replenish GAG fully is related to the differential state of the collagen matrix has been suggested by others, based in part on the finding that GAG depletion corresponds with regions that are positive for the col3/4 epitope, which is indicative of collagen damage [ 6 26 ] . Although we lack specific information on the state of the collagen matrix, the differences observed in the present study (and, indeed, the demonstrated ability to evaluate regional differences in response) suggest that dGEMRIC and model systems such as these may be useful for establishing a better understanding of the capacity of cartilage to repair osteoarthritis-like degradation.
For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.