Words similar to ligands
Example sentences for: ligands
How can you use “ligands” in a sentence? Here are some example sentences to help you improve your vocabulary:
With the recent discovery that bile acids represent the natural ligands for the nuclear receptor FXR [ 10 11 12 ] , there is heightened interest in identifying the genes that are regulated by bile acids.
Complete classification of the genes expressed as a consequence of distinct ligand/receptor interactions during lymphocyte activation will also provide a powerful tool for the assessment and treatment of immunological disorders [ 55 ] . In addition to defining the target genes of specific cytokines and cell surface ligands, it is possible to further subdivide the genes based on the specific signaling proteins and transcription factors that govern their expression.
The specificity profile of the two RAR ligands described here are similar to that of Ch55, a compound with ten times higher affinity for RAR-β than RAR-α, and which can block the growth of certain cancer types [ 4].
We have previously characterized these ligands in cells expressing only δ opioid receptor [ 8 ] . The present study was devised to characterize the activity of a set of opioid ligands in a cell line expressing only μ opioid receptors.
Structure-function analysis of the NCoAs have revealed multiple copies of a signature motif, LXXLL, with conserved spacing that is required for interaction with nuclear receptors and CBP/p300 [ 99 101 ] . Intriguingly, different LXXLL motifs are required for PPARγ (Peroxisome Proliferator activated receptor γ, a gene down-regulated in Tat expressing cells; Acc# L07592, Table 1) function in response to different classes of ligands, suggesting distinct configuration of assembled complexes.
Loading...