Words similar to ligands
Example sentences for: ligands
How can you use “ligands” in a sentence? Here are some example sentences to help you improve your vocabulary:
Such information can not only help explain some of the paradoxical behavioural data of these ligands, but it can also explain the interaction of each ligand with a single receptor involved in modulation of the pain pathways.
A well established method for assessing G-protein activation by opioid receptors and characterizing activity of opioid ligands is measuring the extent of inhibition of forskolin-stimulated adenylyl cyclase (AC) activity [ 12 13 14 21 22 23 ] . Adenylyl cyclase has been implicated in playing a role in mediating the analgesic effect of opioid ligands through μ opioid receptors [ 24 25 26 27 28 ] . Thus, characterizing the ability of opioid ligands to inhibit cAMP production, such as described in this report, could be used as an index for assessing their activity as a correlate of their analgesic effects.
We have previously characterized these ligands in cells expressing only δ opioid receptor [ 8 ] . The present study was devised to characterize the activity of a set of opioid ligands in a cell line expressing only μ opioid receptors.
The IC 50 of all ligands studied were between 1-10 nM, with the exception of etorphine, which was the most potent drug, with an IC 50 of 0.3 nM, morphine, which was the least potent drug with an IC 50 of 12 nM and the endogenous ligand β-endorphin with IC 50 of 500 nM.
The rank order of potency of these ligands was; etorphine>lofentanil≥cyclazocine=xorphanol>met-enkephalin> Win 44,441=hydromorphone≥butorphanol>metazocine=SKF 10047> dezocine≥ nalbuphine>morphine>fentanyl.
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