Words similar to ligand
Example sentences for: ligand
How can you use “ligand” in a sentence? Here are some example sentences to help you improve your vocabulary:
For most amino acids, an alanine substitution was constructed in order to effectively remove any amino acid interaction with the ligand.
The reaction mixtures were diluted 40-fold with cold 20 mM sodium phosphate pH 6.5, 20 mM NaCl, 10% glycerol and immediately ultrafiltrated, repeating twice to ensure removal of free ligand from the complexes.
Statistical analysis showed that most of the agonists tested had efficacies that were not significantly different from that of the endogenous ligand met-enkephalin.
On the other hand, the very high Van der Waals repulsions calculated Table 1(bottom) for alpha4-beta4 and alpha7-alpha7 are a clear indication of a steric clash (Figure 5D): the ligand fits next to Ala 135 of beta2, but cannot accommodate Leu 135 of beta4.
M6P/IGF2R loss of heterozygosity occurs frequently in human breast, liver and lung cancer [ 6 20 21 22 ] , and the remaining allele of 30 to 50% of these tumors contains an intragenic loss-of-function point mutation in the ligand binding domains [ 35 ] . The M6P/IGF2R is also commonly mutated in gastrointestinal and endometrial malignancies because its coding sequence contains a poly-G region that is a mutational target in tumors with mismatch repair deficiencies and microsatellite instability [ 23 24 ] . Functional studies show that the introduction of an exogenous wild-type M6P/IGF2R into human colorectal cancer cells with a single inactivated allele significantly decreases growth rate and enhances apoptosis [ 26 ] . Conversely, loss of M6P/IGF2R expression promotes cancer cell growth by increasing intracellular signaling from both the insulin-like growth factor I receptor and the insulin receptors [ 36 ] .
Loading...