Words similar to ligand
Example sentences for: ligand
How can you use “ligand” in a sentence? Here are some example sentences to help you improve your vocabulary:
Therefore, it may be speculated that TGFβ 1 binding to α V β 6 via this novel ligand recognition motif is facilitating the signaling.
On the other hand, the very high Van der Waals repulsions calculated Table 1(bottom) for alpha4-beta4 and alpha7-alpha7 are a clear indication of a steric clash (Figure 5D): the ligand fits next to Ala 135 of beta2, but cannot accommodate Leu 135 of beta4.
Both ERs enhance transcription from genes with classical estrogen response elements (EREs), but ERα requires less ligand to obtain maximal activation than ERβ [ 25 26 ] . Likewise, both ERs suppress the activity of the TNFα promoter in response to estrogens, but ERβ is a more potent repressor than ERα [ 27 ] . However, some of the most striking isoform-specific differences in gene regulation are observed at promoters, such as that of cyclin D1, which contain AP-1 sites or related cyclic AMP response elements (CREs).
In such calculations, both the protein and ligand can be treated as rigid bodies [ 10 11 ] ; alternately, the ligand, the protein, or both molecules, can be completely or partially flexible [ 12 13 ] .
A rapid docking procedure with flexible ligand and a grid representation of the receptor was followed by an extensive Monte Carlo energy minimization with both ligand and receptor side chains flexible (see "Materials and Methods" for details).
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