Words similar to lifr

Example sentences for: lifr

How can you use “lifr” in a sentence? Here are some example sentences to help you improve your vocabulary:

Thus, the corticotrophs did not seem altered by LIFR loss using this method of assessment.
The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.
The observed GC activity excess suggests that LIF and LIFR are integral to GC regulation, but that the relationship is complex and that alterations in GC response are likely to result from altered balance of the GC response cascade induced both by gain and loss of LIFR function.
However, many of the defects caused by gp130 loss are shared by mice with a null mutation of LIFR, reflecting the heterodimeric relationship of LIFR and gp130 for functional LIFR:gp130 signaling.
LIFR is known to be important in the balance between bone resorption and bone formation acting directly on osteoblasts [ 55 56 57 ] . Bone loss in the untreated control Lifr -/- pups suggests a heightened response to GC rather than a heightened response to the bone-remodeling effects of progesterone.