Words similar to lif
Example sentences for: lif
How can you use “lif” in a sentence? Here are some example sentences to help you improve your vocabulary:
LIF and CNTF stimulate muscle regeneration in vivo [ 62 63 ] , as do other growth factors; such as insulin-like growth factor [ 64 65 ] . The power of LIF to regenerate muscle is seen in dystrophin null mdx mice, where exogenous LIF regenerates atrophied diaphragm muscle [ 66 ] . LIF induced signaling appears to be essential in muscle development as seen by muscle atrophy in the absence of LIFR on E18.
Animal models of LIF over expression and ablation have confirmed importance in stress regulation.
Other LIF effects that may influence the stress response through actions in the rodent nervous system are a LIF induced increase in acetylcholine [ 20 ] and LIF induced decreases in neuropeptide Y and tyrosine hydroxylase [ 21 ] . LIFR:gp130 signaling has strong effects in systems peripheral to but influenced by the HPA including reproductive, skeletal, nervous, neuromuscular, cardiovascular, hematopoietic, immune and metabolic systems, with influences on both development and adult homeostasis [for reviews see [ 7 22 23 24 25 26 27 ] ].
The observed GC activity excess suggests that LIF and LIFR are integral to GC regulation, but that the relationship is complex and that alterations in GC response are likely to result from altered balance of the GC response cascade induced both by gain and loss of LIFR function.
Excess GC activity due to LIFR loss is an unexpected result since LIF gain-of-function mice develop a Cushing's-like syndrome [ 29 30 ] . Thus, if the relationship were simple, loss of LIFR function would predict development of GC insufficiency.
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