Example sentences for: lif

How can you use “lif” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Recent evidence indicates that the cytokine, leukemia inhibitory factor (LIF) and its functional binding to the high affinity receptor, a heterodimer between low-affinity LIFR and glycoprotein 130 (LIFR:gp130), are players within the HPA cascade of events.

  • LIF and LIFR are functionally expressed in rodent tissues that are central to GC production: the hypothalamus [ 8 ] and pituitary [ 9 10 11 12 ] . LIF works in synergy with corticotropin-releasing hormone (CRH) in the hypothalamus to increase pituitary pro-opiomelanocortin (POMC) and, ultimately, pituitary adrenocorticotrophin hormone (ACTH) [ 9 11 13 14 15 16 ] . LIF also stimulates POMC gene expression directly in the pituitary [ 9 11 15 17 ] . LIF up-regulates pituitary prohormone convertase (PC1).

  • All ES cell lines were cultured on mitotically inactivated primary embryonic fibroblasts in ES cell medium supplemented with recombinant leukemia inhibitory factor (LIF) as described elsewhere [ 22 ] . F3 cells were generated by introducing 100 μg of Not1 digested pΔHPRT plasmid into 1.5 × 10 8R1 ES cells by electroporation at 250 volts/500μf/resistance 8 using a BTX ECM600 electroporation system [ 7 ] . Cells containing neo were selected by supplementing the ES cell medium with 250 μg/ml Geneticin (G418, Gibco-BRL) and negative selection against Hsv-tk gene expression was achieved by including 2 μM gancyclovir (Roche).

  • Animal models of LIF over expression and ablation have confirmed importance in stress regulation.

  • Adult mouse LIF over expression mediated by transfer of LIF over expressing hematopoietic cells results in a lethal, multi-systemic phenotype that includes small adrenals with a loss of the innermost cortical layer [ 28 ] . Pituitary specific LIF over expression leads to a Cushing's Syndrome-like condition of GC hyperactivity [ 29 30 ] . LIF null adult mice have normal or slightly reduced basal ACTH and GC concentrations, and are unable to respond to acute stress by increased ACTH.


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