Example sentences for: lif

How can you use “lif” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • JM-1 ES cells [ 22] were expanded by culturing on feeder cells in medium supplemented with LIF.

  • Cells were plated on thirteen 10 cm 2tissue culture dishes and grown for two days in ES cell medium supplemented with LIF.

  • Basal POMC is reduced, but inducible upon stress [ 16 ] . Thus, an obligatory function of LIF may be in the processing of POMC to ACTH during acute stress.

  • Excess GC activity due to LIFR loss is an unexpected result since LIF gain-of-function mice develop a Cushing's-like syndrome [ 29 30 ] . Thus, if the relationship were simple, loss of LIFR function would predict development of GC insufficiency.

  • LIF and LIFR are functionally expressed in rodent tissues that are central to GC production: the hypothalamus [ 8 ] and pituitary [ 9 10 11 12 ] . LIF works in synergy with corticotropin-releasing hormone (CRH) in the hypothalamus to increase pituitary pro-opiomelanocortin (POMC) and, ultimately, pituitary adrenocorticotrophin hormone (ACTH) [ 9 11 13 14 15 16 ] . LIF also stimulates POMC gene expression directly in the pituitary [ 9 11 15 17 ] . LIF up-regulates pituitary prohormone convertase (PC1).


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