Words similar to lif
Example sentences for: lif
How can you use “lif” in a sentence? Here are some example sentences to help you improve your vocabulary:
Excess GC activity due to LIFR loss is an unexpected result since LIF gain-of-function mice develop a Cushing's-like syndrome [ 29 30 ] . Thus, if the relationship were simple, loss of LIFR function would predict development of GC insufficiency.
Other LIF effects that may influence the stress response through actions in the rodent nervous system are a LIF induced increase in acetylcholine [ 20 ] and LIF induced decreases in neuropeptide Y and tyrosine hydroxylase [ 21 ] . LIFR:gp130 signaling has strong effects in systems peripheral to but influenced by the HPA including reproductive, skeletal, nervous, neuromuscular, cardiovascular, hematopoietic, immune and metabolic systems, with influences on both development and adult homeostasis [for reviews see [ 7 22 23 24 25 26 27 ] ].
Basal POMC is reduced, but inducible upon stress [ 16 ] . Thus, an obligatory function of LIF may be in the processing of POMC to ACTH during acute stress.
LIF is also responsible for increased GFAP expression [ 69 ] , while signaling through LIFR:gp130 is critical in fostering the differentiation of neuronal precursors into astrocytes [ 70 ] mediated through STAT3 [ 71 72 73 74 ] . Glial cells respond to GC, which, in turn, can affect transcriptional control of GFAP level either positively or negatively [ 74 ] . The present study shows that GC's can play a critical role in hindering astrocyte development in the absence of LIFR as seen through the partial abrogation of this defect following exposure to RU486 in Lifr -/- mice.
Cells were plated on thirteen 10 cm 2tissue culture dishes and grown for two days in ES cell medium supplemented with LIF.
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