Example sentences for: lif

How can you use “lif” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All ES cell lines were cultured on mitotically inactivated primary embryonic fibroblasts in ES cell medium supplemented with recombinant leukemia inhibitory factor (LIF) as described elsewhere [ 27].

  • Adult mouse LIF over expression mediated by transfer of LIF over expressing hematopoietic cells results in a lethal, multi-systemic phenotype that includes small adrenals with a loss of the innermost cortical layer [ 28 ] . Pituitary specific LIF over expression leads to a Cushing's Syndrome-like condition of GC hyperactivity [ 29 30 ] . LIF null adult mice have normal or slightly reduced basal ACTH and GC concentrations, and are unable to respond to acute stress by increased ACTH.

  • The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.

  • Cells were plated on thirteen 10 cm 2tissue culture dishes and grown for two days in ES cell medium supplemented with LIF.

  • LIF - leukemia inhibitory factor


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