Example sentences for: ligand-binding

How can you use “ligand-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.

  • In this report we show that HSPLs can be isolated that bind to human TNFR2 at its ligand-binding site and subdivide it into multiple hotspots.

  • Gene fusions characteristically bring together proteins that function in a concerted manner, such as successive enzymes in metabolic pathways, enzymes and the domains involved in their regulation, or DNA-binding domains and ligand-binding domains in prokaryotic transcriptional regulators [ 1, 2, 3].

  • These include the PAS-like fold, which is the scaffold of the PAS [ 11 12 ] , GAF [ 13 ] , and probably the CACHE [ 14 ] superfamilies, and the ACT-like fold, which is seen in ACT, ferredoxin and related ligand-binding domains [ 4 15 ] . Identification of such conserved domains has, often, improved our understanding of the general structural and biochemical features that underlie protein-small molecule interactions.

  • While we cannot rule out possible allosteric interactions between the peptides, the data suggests that the HSPLs were able to dissect the ligand-binding region of TNFR2 into several structural and/or functional hotspots.


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