Words similar to ligand-binding
Example sentences for: ligand-binding
How can you use “ligand-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
These include the PAS-like fold, which is the scaffold of the PAS [ 11 12 ] , GAF [ 13 ] , and probably the CACHE [ 14 ] superfamilies, and the ACT-like fold, which is seen in ACT, ferredoxin and related ligand-binding domains [ 4 15 ] . Identification of such conserved domains has, often, improved our understanding of the general structural and biochemical features that underlie protein-small molecule interactions.
The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.
Structural diversity of these extracellular loops and transmembrane domains is believed to reflect ligand-binding specificity of ORs [ 1, 42].
In this experiment, mRNAs from whole brains of mice of different genetic backgrounds which had been treated with an antagonist directed against the ligand-binding domain of a seven-transmembrane neuropeptide receptor [ 26] (the corticotropin-releasing hormone receptor 1 (CRH-R1) [ 27]) were compared to mRNAs from brains of mice lacking a functional CRH-R1 (CRH-R1 knockout mice [ 28]) using cDNA-microarrays (Table 1).
Meloidogyne extracellular mappings (15 clusters) were all within the category of SCP/Tpx-1/Ag5/PR-1/Sc7 extracellular proteins (InterPro domain IPR001283) and showed homology to the genes vap-1 from H. glycines and Mi-msp-1 from M. incognita [ 40 41 ] , both venom allergen antigen 5 family members with homologs in numerous nematodes including hookworms and C. elegans [ 42 ] . Categories that particularly contributed to the abundance of ligand-binding/carrier mappings for Meloidogyne included EF-hand calcium binding (22 clusters), RNA recognition motif (18 clusters), and a variety of ATP-binding domains (20 clusters).
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