Words similar to ligand-binding
Example sentences for: ligand-binding
How can you use “ligand-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
A similar secondary structure pattern is also observed in several other ligand-binding domains such as the PAS, GAF, profilin and probably even the CACHE domains [ 10 ] . Sequence-structure threading using the 3DPSSM method detected the PAS domain (Photoactive yellow protein PDB: 1drm) with marginally significant scores (.5, 50-70% probability of correct fold prediction).
We tested 3 different monoclonal antibodies, which originally were generated against Drosophila nAChR subunits for their cross-reactivity in the blowfly Calliphora erythrocephala . Two of these antibodies were directed against ligand-binding subunits (ALS and Dα2) whereas the third was directed against a structural subunit (ARD) of the Drosophila nAChR [ 25].
All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.
The ligands ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and a novel neurotrophin set, known alternatively as NNT-1/BSF3 and CLF/CLC, also function through the high affinity LIFR:gp130 heterodimeric receptor but require a third ligand-binding but non-signaling subunit [ 1 2 3 4 ] . Oncostatin M (OSM) utilizes LIFR:gp130 as an alternative receptor complex for OSM signaling in humans [ 5 ] , but not in mice [ 6 ] . Thus, in mice LIFR:gp130 is obligatory for signaling induced by LIF, CNTF, CT-1 and CLF/CLC.
In summary, HSPLs were isolated with which we were able to dissect the ligand-binding domain of a natural receptor and generate information about novel and unexpected bioactivities.
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