Example sentences for: ligand-binding

How can you use “ligand-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These include the PAS-like fold, which is the scaffold of the PAS [ 11 12 ] , GAF [ 13 ] , and probably the CACHE [ 14 ] superfamilies, and the ACT-like fold, which is seen in ACT, ferredoxin and related ligand-binding domains [ 4 15 ] . Identification of such conserved domains has, often, improved our understanding of the general structural and biochemical features that underlie protein-small molecule interactions.

  • In three of these cell lines, LNCaP, MDA PCa 2a and MDA PCa 2b, mutations in the ligand-binding domain of the AR confer broad steroid-binding affinity [ 8, 9].

  • Gene fusions characteristically bring together proteins that function in a concerted manner, such as successive enzymes in metabolic pathways, enzymes and the domains involved in their regulation, or DNA-binding domains and ligand-binding domains in prokaryotic transcriptional regulators [ 1, 2, 3].

  • Fluorescent probes can be used to directly label ligand-binding sites without the use of radioactivity or antibodies.

  • We tested 3 different monoclonal antibodies, which originally were generated against Drosophila nAChR subunits for their cross-reactivity in the blowfly Calliphora erythrocephala . Two of these antibodies were directed against ligand-binding subunits (ALS and Dα2) whereas the third was directed against a structural subunit (ARD) of the Drosophila nAChR [ 25].


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