Words similar to ligand-binding
Example sentences for: ligand-binding
How can you use “ligand-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
The NR family contains two related ERs (ERα and ERβ) that conform to the typical three domain NR structure and share extensive sequence homology in the DBD and LBD region [ 20 21 ] . Analysis of the function of the individual ERs in mouse knockout models suggests that the major proliferative effects of estrogen are mediated by ERα and not by ERβ, which seems to play an inhibitory role in proliferation in some studies [ 22 23 ] . The ligand-binding properties of the ERs are different, with ERβ often exhibiting stronger binding to plant-derived phytoestrogens [ 24 ] . More importantly, the ERs exhibit isoform-specific effects on gene expression.
These include the PAS-like fold, which is the scaffold of the PAS [ 11 12 ] , GAF [ 13 ] , and probably the CACHE [ 14 ] superfamilies, and the ACT-like fold, which is seen in ACT, ferredoxin and related ligand-binding domains [ 4 15 ] . Identification of such conserved domains has, often, improved our understanding of the general structural and biochemical features that underlie protein-small molecule interactions.
Fluorescent probes can be used to directly label ligand-binding sites without the use of radioactivity or antibodies.
One model of a ligand-binding pocket in ORs stipulates the existence of 20 variable amino-acid residues on transmembrane helices 3,4 and 5 that constitute the putative ligand 'complementarity-determining region' [ 5, 42].
Meloidogyne extracellular mappings (15 clusters) were all within the category of SCP/Tpx-1/Ag5/PR-1/Sc7 extracellular proteins (InterPro domain IPR001283) and showed homology to the genes vap-1 from H. glycines and Mi-msp-1 from M. incognita [ 40 41 ] , both venom allergen antigen 5 family members with homologs in numerous nematodes including hookworms and C. elegans [ 42 ] . Categories that particularly contributed to the abundance of ligand-binding/carrier mappings for Meloidogyne included EF-hand calcium binding (22 clusters), RNA recognition motif (18 clusters), and a variety of ATP-binding domains (20 clusters).
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