Words similar to ligand-dependent
Example sentences for: ligand-dependent
How can you use “ligand-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
This positive response to 9-cis-RA contrasts with the inhibition that would result from the loss of RXR to ligand-dependent homodimers [ 20 ] , confirming that these studies reflect the activity of CAR/RXR heterodimers and demonstrating that such complexes can be permissive for RXR signaling.
Upon addition of 1 μM dexamethasone (Dex) the receptor is translocated into the nucleus within 10 min [ 48 ] . When GR-GFP was co-expressed with the wild-type Rab24 in NIH3T3 cells, we observed normal ligand-dependent translocation of GR-GFP into the nucleus when Dex was applied (Fig.
These levels of ligand-dependent activation were similar to those observed with the original hammerhead aptazyme constructs, [ 21 ] and it may prove possible to use in vitro selection to further optimize activation [ 13 14 ] . However, when the time course data were fit with a single exponential equation, the rates of the initial reactions turned out to be very similar in both the presence and absence of theophylline (Table 2).
For example, it is possible that the inhibitory effect of LG1069 in the stable CAR expressing cell line is based on the sequestration of limiting amounts of RXR into ligand-dependent homodimers, as has been suggested in previous studies using primary hepatocytes [ 17 ] . However, similar effects were observed with the relatively large amounts of RXR used for the biochemical studies or with the transient transfections, which relied on cotransfected RXR.
This receptor has previously been shown to elevate intracellular Ca 2+and activate CamKII in a ligand-dependent manner [ 6 37 38 ] . C57mg cells stably transformed with Rfz-2/β 2 AR retrovirus or wt C57mg cells were treated overnight with propranolol, a β 2 AR antagonist, to maintain the chimeric receptors in an inactivated state.
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