Words similar to ligand-dependent
Example sentences for: ligand-dependent
How can you use “ligand-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
In other cases, however, the balance of coactivator and corepressor recruitment is regulated by direct competition for the AF-2 surface, rather than ligand-dependent coregulator exchange.
Upon addition of 1 μM dexamethasone (Dex) the receptor is translocated into the nucleus within 10 min [ 48 ] . When GR-GFP was co-expressed with the wild-type Rab24 in NIH3T3 cells, we observed normal ligand-dependent translocation of GR-GFP into the nucleus when Dex was applied (Fig.
No significant change in the extent of ligand-dependent activation was observed following pre-incubation (data not shown).
Similarly, ligand-dependent targeted proteolysis of several nuclear receptors has been observed [ [ 39 40 41 42 ] ]. In the estrogen receptor, the RARα, and the RXRα, deletion of the α-helix H12 of the ligand binding domain which is essential for ligand-dependent activation stabilises these proteins showing that proteolysis and transactivation are intimately linked [ [ 42 43 44 ] ]. In the case of nuclear receptors, their targeted proteolysis in the presence of ligand may be a mechanism for attenuating the physiological response to the ligand.
For example, it is possible that the inhibitory effect of LG1069 in the stable CAR expressing cell line is based on the sequestration of limiting amounts of RXR into ligand-dependent homodimers, as has been suggested in previous studies using primary hepatocytes [ 17 ] . However, similar effects were observed with the relatively large amounts of RXR used for the biochemical studies or with the transient transfections, which relied on cotransfected RXR.
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