Words similar to ligand-independent

Example sentences for: ligand-independent

How can you use “ligand-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

This oncogenic mutation has been found in human basal cell carcinoma [ 3 ] and the correspondingly mutated protein is capable of ligand-independent activation of the Hh pathway in cell-culture assays [ 11 ] . A kinetic and saturation binding assay with Smo act-containing membranes showed that this mutant protein binds the Hh agonist with an affinity identical to that of Smo wt(data not shown).
Both MAP kinase and STAT pathways are involved in AR-dependent regulation and in ligand-independent activation of the AR [ 18 ] . Differential expression of aldehyde dehydrogenase 1A1 and alcohol dehydrogenase 1B, enzymes that affect retinoic acid biosynthesis, suggest that other signaling pathways may participate in the AR-initiated programs of external genital differentiation [ 19 20 ] .
ERβ did not bind two of these smaller fragments of N-CoR (1944-2033; 2230-2322) that contain known ID motifs (IDs 3 and 1 [ 16 ] ). ERβ bound weakly to two regions of N-CoR (2033-2123; 2123-2230), one of which (2033-2123) contains an ID motif (ID2), but did so in a ligand-independent fashion.