Words similar to ligand-independent

Example sentences for: ligand-independent

How can you use “ligand-independent” in a sentence? Here are some example sentences to help you improve your vocabulary:

ERβ did not bind two of these smaller fragments of N-CoR (1944-2033; 2230-2322) that contain known ID motifs (IDs 3 and 1 [ 16 ] ). ERβ bound weakly to two regions of N-CoR (2033-2123; 2123-2230), one of which (2033-2123) contains an ID motif (ID2), but did so in a ligand-independent fashion.
Both MAP kinase and STAT pathways are involved in AR-dependent regulation and in ligand-independent activation of the AR [ 18 ] . Differential expression of aldehyde dehydrogenase 1A1 and alcohol dehydrogenase 1B, enzymes that affect retinoic acid biosynthesis, suggest that other signaling pathways may participate in the AR-initiated programs of external genital differentiation [ 19 20 ] .
This oncogenic mutation has been found in human basal cell carcinoma [ 3 ] and the correspondingly mutated protein is capable of ligand-independent activation of the Hh pathway in cell-culture assays [ 11 ] . A kinetic and saturation binding assay with Smo act-containing membranes showed that this mutant protein binds the Hh agonist with an affinity identical to that of Smo wt(data not shown).