Words similar to liganded
Example sentences for: liganded
How can you use “liganded” in a sentence? Here are some example sentences to help you improve your vocabulary:
RIP140, Hairless and DAX possess NR boxes that interact with AF-2 [ 11 13 19 ] and these corepressors act as negative regulators of the activity of the liganded NR.
NR interactions with N-CoR are usually mediated by a hydrophobic cleft that spans residues from H3 and H5 and includes residues that lie under H12 in the liganded configuration [ 4 17 ] . These interactions are either independent of, or inhibited by, NR H12 [ 17 39 42 ] . By contrast, NR interactions with coactivators are mediated by residues from the upper part of H3-H5 and also require H12 itself [ 18 ] . Fig.
[ 5, 6], which revealed that the hormone insensitivity produced by cellular transformation with v-mos (a serine/threonine protein kinase that acts as an oncogene) results from both a decrease in the nuclear retention of liganded receptor and a decrease in the reutilization of GR protein that cycles back into the cytoplasm.
The fact that the mode of ERβ interaction with N-CoR resembles that of NRs with coactivators [ 4 ] , or with corepressors that modulate the activity of liganded NR complexes, such as RIP140 [ 10 ] , raises the possibility that ERβ may be able to recruit N-CoR and SMRT to estrogen-regulated promoters in response to agonists and that the balance of overall ERβ activity in the presence of estrogens may be regulated by competition between p160s and corepressors for the same ERβ AF-2 surface.
The NcoA family members constitute SRC-1/NcoA-1 [ 89 ] , TIF2/GRIP1/NcoA-2, [ 94 95 ] and pCIP/ACTR/AIB1 [ 96 97 98 ] proteins, which interact with liganded RA receptor (RAR), and CBP/p300.
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