Example sentences for: ligases

How can you use “ligases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The ubiquitination of proteins is regulated through precise selection of protein substrates by specific E3 ubiquitin ligases (Pickart 2001).

  • The cullin/RING family of ubiquitin ligases comprises a multifunctional set of enzymes controlling the stability and activity of cell cycle regulators, transcription factors, and signaling proteins (reviewed in ref.

  • Although the molecular signaling mechanisms that transduce the effects of phasic patterns of work activity to modify muscle mass are incompletely understood, recent evidence implicates pathways that include the signaling molecules PI3 kinase, Akt, mTOR, S6K, and ERK, the ubiquitin ligases MAFbx and MuRF1, and transcription factors of the FOX superfamily in the control of both catabolic and anabolic processes [21,22,23,24].

  • Many RING-finger-containing proteins that may act as ubiquitin ligases under certain conditions have otherwise diverse structures and functions [ 32 ] . It is clear that Siah can act in the ubiquitin pathway, targeting some proteins for proteolysis, under certain circumstances.

  • As Pcu3p-associated ubiquitin ligase activity was not described before, we first needed to determine which of the fourteen different ubiquitin-conjugating enzymes (UBCs) present in the fission yeast genome associate with the RING domain protein Pip1p, an essential cofactor of cullin ubiquitin ligases [ 7, 28, 29, 30].


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