Words similar to ligases
Example sentences for: ligases
How can you use “ligases” in a sentence? Here are some example sentences to help you improve your vocabulary:
Regardless of the exact mechanism, CSN may regulate the activity of multiple cullin ubiquitin ligases through counteracting their stimulatory Ned8p modification.
The F-box-containing proteins of the SCF complex constitute a family of E3 ligases, key components of the ubiquitin-proteasome pathway [ 67 ] , as are many RING finger proteins [ 68 ] . The RING finger motif is thought to mediate protein-protein interactions and E3 ligase complex assembly.
In addition to the key roles in E3 ligase activity, RING finger domains have also been shown to be important for regulating subcellular localization of E3s and/or their substrates in a number of cases [ 53 54 55 56 ] . Studies have shown the MDM2 RING finger domain is required to promote nuclear export of p53 and this activity of MDM2 RING finger seems to be coupled with its ability to promote ubiquitination of p53 [ 53 54 55 ] . Rbx1/ROC1, the small RING finger subunit of the SCF E3 complexes, promotes the nuclear accumulation of Cul1, another subunit of the SCF complexes [ 56 ] . These studies have suggested a correlation between the ubiquitination activities of RING fingers and their roles in regulating subcellular localization of the E3 ligases which they are part of.
Both methods allow similarly large numbers of mutational variants to be simultaneously compared and competed, and both methods can potentially be adapted to a range of molecular biology enzymes that act on their own templates, such as restriction endonucleases or DNA ligases.
Within the past few years, the RING finger motif has emerged as a core structure feature for many ubiquitin ligases (E3s) [ 52 ] . In most cases, RING fingers function as E2 recruiting domains, and by directly interacting with E2s, bring E2s in the vicinity of ubiquitination substrates, which bind to other parts of the RING finger proteins or other subunits of the RING finger protein containing complexes.
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