Words similar to ligases
Example sentences for: ligases
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The anti-theophylline aptamer was attached at the same point as had previously proven successful in the design of theophylline-dependent cleavases and ligases [ 13 14 ] .
While Csn5 is thought to impede the action of ubiquitin ligases through shaving cullins from their Rub1/Nedd8 modification (and possibly also by deubiquitinating substrates bound to the cullins), the outcome of Rpn11 inhibition will depend largely on whether Rpn11 participates primarily in shaving substrates from their chains, promoting release and rescue, or in trimming the polyubiquitin tag, allowing for proteolysis quality control (Figure 2).
The F-box-containing proteins of the SCF complex constitute a family of E3 ligases, key components of the ubiquitin-proteasome pathway [ 67 ] , as are many RING finger proteins [ 68 ] . The RING finger motif is thought to mediate protein-protein interactions and E3 ligase complex assembly.
In addition to the key roles in E3 ligase activity, RING finger domains have also been shown to be important for regulating subcellular localization of E3s and/or their substrates in a number of cases [ 53 54 55 56 ] . Studies have shown the MDM2 RING finger domain is required to promote nuclear export of p53 and this activity of MDM2 RING finger seems to be coupled with its ability to promote ubiquitination of p53 [ 53 54 55 ] . Rbx1/ROC1, the small RING finger subunit of the SCF E3 complexes, promotes the nuclear accumulation of Cul1, another subunit of the SCF complexes [ 56 ] . These studies have suggested a correlation between the ubiquitination activities of RING fingers and their roles in regulating subcellular localization of the E3 ligases which they are part of.
The cullin/RING family of ubiquitin ligases comprises a multifunctional set of enzymes controlling the stability and activity of cell cycle regulators, transcription factors, and signaling proteins (reviewed in ref.
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