Example sentences for: activation

How can you use “activation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To further characterize the mechanism of activation of Rlk/Txk, we studied the nature of Rlk's localization and interaction with Src family kinases.

  • TGF-β family proteins, including β1,β2 and β3, induce TNF-resistance and suppress the PH-20 effect of increasing TNF cytotoxicity in murine L929 fibroblasts [ 8 11 ] . TGF-β1 induces a novel extracellular matrix protein that prevents TNF-mediated cell death and blocks the activation of extracellular signal-regulated kinase (ERK; also known as p42/44 mitogen-activated protein kinase, p42/44 MAPK) in L929 cells [ 8 12 ] . Additionally, TGF-β1 induces the expression of TIAF1 (TGF-β-induced antiapoptotic factor) [ 13 ] and TIF2 (TGF-β-induced factor 2) [ 14 ] that inhibit TNF cytotoxicity.

  • We hypothesized that increased expression of wild-type protein might result in modest activation of the pathway, while expression of mutant, stabilized protein would increase Wnt signaling activity more significantly.

  • Rapamycin inhibits activation of p70 S6 kinase, a downstream effector in the PI 3-kinase signaling pathway [ 13 ] . Rapamycin forms a complex with FK506-binding protein 12 and this complex blocks the kinase activity of mTOR (mammalian target of rapamycin), a kinase upstream of p70 S6 kinase [ 20 ] . The IC 50 for p70 S6 kinase inhibition by rapamycin is ~0.

  • A vector expressing hCAF1 (pVP16-hCAFl) or hPOP2 (pVP16-hPOP2) fused to the VP16 activation domain was also produced (Fig.


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