Example sentences for: activates

How can you use “activates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One possibility is that a Fz receptor protein complex directly interacts with and activates proteins that stimulate the cytoskeleton to produce a hair (Fig.

  • The 5-HT 2C receptor activates multiple signal transduction cascades in vivo and in heterologous expression systems (see Raymond et al 2001 [ 22 ] ; and Gerhardt and van Heerikhuizen, 1997 ( [ 5 ] , for reviews).

  • In the present study, utilizing confocal microscopy and Affymetrix arrays, we have shown that at least one component of the neurotoxicity of mefloquine can be attributed to an effect on the ER calcium store, and that the drug activates a UPR similar to that induced by agents known to disrupt ER function.

  • Together with the DNA binding protein TCF, β-catenin activates expression of Wnt target genes.

  • Fas contains a single transmembrane domain and belongs to the tumor necrosis factor (TNF)/nerve growth factor family [ 8 ] . FasL contains a single transmembrane domain and is also a member of the same TNF family [ 9 ] . A soluble form of FasL has been described, but appears to be less capable of inducing apoptosis, when compared with the bound form [ 10 11 ] . The binding of FasL with Fas initiates receptor oligomerization, which recruits Fas-associated death domain (FADD) [ 12 ] . FADD binds procaspase-8 and permits activation of caspase-8 through self-cleavage [ 13 ] . Caspase-8 activates the effector caspases, which commits the cell to the orderly process of apoptosis [ 14 15 ] . In addition, caspase-8 cleaves Bcl-2-interactive-death-agonist (Bid) [ 16 ] . Truncated Bid localizes to the mitochondria and promotes cytochrome c release; this process also serves as a major apoptotic-signaling pathway for Fas [ 16 17 18 ] . Depending upon the amount of caspase-8 that is activated, the predominant pathway can be either Bid cleavage with subsequent mitochondrial release of cytochrome c or activation of the effector caspase pathway [ 18 ] . Resident cells of the kidney express both Fas and FasL and Fas/FasL signaling is functional in these cells [ 19 20 21 22 23 24 ] . A recent review by Ortiz and associates [ 25 ] noted that the combined literature demonstrating participation of Fas/FasL pathway in renal injury essentially fulfilled Koch's postulates.


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