Words similar to activates
Example sentences for: activates
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The theoretical link between statins and ROCK1 goes as follows: statins inhibit the isoprenoid pathway, isoprenoids are regulators of the enzyme Rho, and Rho in turn activates ROCK1.
In contrast, C-terminal truncation of PP5 activates the enzyme as extensively as lipid treatment, and little further activation is seen with lipid [ 19 ] . In the case of PP5, subtilisin digestion removed both the TPR domain and the C terminus [ 19 ] . The observation that C-terminal truncation increased Ppt1p activity toward both 32P-casein and 32P-MBP, but subtilisin digestion increased activity only toward 32P-MBP (see Fig.
The mechanism by which the (K395A/3F)Syk molecule activates endogenous Syk is unknown.
PH-20 blocks TGF-β1-mediated growth suppression of epithelial cells [ 8 15 ] . Additionally, PH-20 rapidly activates ERK in L929 cells and TGF-β1 reduces the PH-20-induced ERK activation [ 16 ] . In contrast, TGF-β1 synergistically increases PH-20-mediated inhibition of staurosporine apoptosis [ 16 ] . Thus, PH-20 and TGF-β1 are physiological antagonists for only certain cellular responses.
Signaling by the IGF-IR has been studied in many different cell types and is important for proliferation, survival, motility, adhesion, transformation, tumor formation and metastasis [for reviews see refs [ 31 32 ] ]. The receptor can directly phosphorylate the insulin receptor substrate 1 (IRS-1) and Shc proteins in the intact cell causing activation of PI-3Kinase and ras signaling [ 33 ] . More recently, it has been shown that the IGF-IR signals via the Gβγ subunits of the heterotrimeric Gi complex to stimulate PI-3Kinase and ras, and also activates the JAK/Stat pathway to cause phosphorylation of Stat3 [ 34 35 ] .
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