Words similar to activates
Example sentences for: activates
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The phosphonate group of the NMDA antagonist binds to the glutamate-receptor, as does the natural agonist glutamic acid, but no conformational change that activates the NMDA channel occurs [ 28 ] . Beart et al [ 21 ] performed a SAR analysis of this type of NMDA antagonists.
Ligand binding activates the kinase, resulting in autophosphorylation and initiation of a series of phosphotransfer reactions that culminates with the activation of a response regulator protein that functions as the effector component of the pathway.
Cell adhesion to III1-C activates ERK1/2
The possibility that domoic acid may activate neonatal microglia both in vitro and in vivo is suggested by recent observations with kainic acid, a domoic acid and glutamate analog that can induce upregulation of neonatal microglia scavenger receptor mRNA [ 22 ] and tissue plasminogen activator release [ 23 ] . The putative molecular explanation for these observations has been that kainic acid activates the ionotropic AMPA glutamate GluR4 subunit which has recently been shown to be expressed by activated microglia following transient forebrain ischemia in vivo [ 24 ] . Because this subunit of the AMPA glutamate receptor has affinity for domoic acid [ 25 26 27 ] , we hypothesized that domoic acid might activate neonatal microglia in vitro and lead to concomitant mediator release [ 21 ] .
These results argue that the agonist activates the pathway downstream of the Hh-Ptc interaction while cyclopamine, Cur61414 and the agonist may act at a similar level in the Hh-signaling cascade.
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