Example sentences for: activated

How can you use “activated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Unlike SIRT-1, these related enzymes are known to increase longevity when activated, usually by restricting the organism's calorie intake.

  • Activated AKT was more abundant in tumors that were Wnt-1 TG, Pten +/- with LOH, as has been shown for uterine tumors in Pten heterozygous mice (KP, RP, submitted).

  • Several lines of evidence indicate that NF-κB is constitutively activated in cancer cells, suggesting that it plays an important role in tumorigenesis [ 30 ] . Activated glucocorticoid receptors have been shown to repress NF-κB-mediated gene expression [ 31 ] , and to cause a significant reduction in nuclear levels of p65 protein, a subunit of NF-κB [ 31 ] . A variety of mitogens, cytokines, and reactive oxygen intermediates have been shown to rapidly cause the translocation of NF-κB to the nucleus [ 30 31 32 ] , and the ability of dexamethasone to interfere with this translocation is blocked by prior treatment with the glucocorticoid antagonist RU 486 [ 30 ] . Based on these findings, it is plausible to speculate that exposure to RU 486 may interfere with the function of endogenous glucocorticoids as regulators of cell cycle, allowing the initiation and progression of malignant transformation of liver cells.

  • This suggests that proteins, such as PhoP, that require activation to promote transcription may not be approachable with this method unless the over-expressed regulatory protein can also be activated.

  • Like other steroid hormone receptors, GRs are phosphoproteins, and reversible phosphorylation of specific ser/thr residues on the GR or associated proteins has been implicated in the regulation of 1) hormone binding to the cytoplasmic GR-complex, 2) the translocation of the GR between the cytoplasm and the nucleus, 3) the binding of ligand activated GR to consensus GRE in the promoter regions of GR-responsive genes, and 4) the formation of an active transcriptional complex [ 1, 2, 5, 6, 7, 8, 28, 29, 30, 31].


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