Example sentences for: activate

How can you use “activate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • lanes 2 & 3), confirming that tyrosine phosphorylated Cas SD can inhibit the ability of v-crk to activate the JNK pathway.

  • Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .

  • Both have been shown to elevate intracellular Ca 2+levels and to activate PKC and CamKII [ 4 5 6 ] . In addition Wnt-5a and Rfz-2 have been shown to synergize in their induction of CamKII [ 6 ] . Wnt-1/C57mg cells were also used for comparison, in an effort to identify genes preferentially regulated by Wnt-5a.

  • A simple two-state model (Figure 8a) predicts that the agonist (Ag, green square) and the antagonist (Ant, pink circle) compete for the same site on Smo to activate or inactivate Hh-pathway signaling.

  • Because of the high catalytic efficiency and broad substrate specificity, β-lactamases have been extensively used in the ADEPT approach to activate prodrugs of vinca alkaloids [ 27 ] , nitrogen mustard [ 28 29 30 31 32 ] , doxorubicin [ 33 34 35 36 ] and others [ 37 ] . To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized β-lactam prodrugs.


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