Words similar to ach

Example sentences for: ach

How can you use “ach” in a sentence? Here are some example sentences to help you improve your vocabulary:

2a, middle) with no change in the magnitude of the Cl -current in response to Ach (2681 ± 281 nA vs. 2785 ± 186 nA, Fig.
In the present study, we used a cholinergic cell line, SN56 [ 17 ] , which is derived from the fusion of septal neurons of postnatal day 21 mice with N18TG2 murine neuroblastoma cells, as a model for cholinergic neurons, in order to determine the possible role of PLD 1 and PLD2 in generating choline for ACh synthesis.
However, our observations that PLD1 overexpression increases ACh production form endogenous sources suggest that PLD1 may serve the same function as PLD2 in other cholinergic cells.
Significantly, among the five subtypes of muscarinic ACh receptors (MAChRs), Ml and M3 receptors have been shown to efficiently activate PLD (and PKC) in various cell types [ 26 27 28 29 30 ] , whereas activation of PLD by M2 and M4 receptors is less robust [ 26 ] . These observations suggest that in a cholinergic synapse, ACh released into the synaptic cleft might stimulate PLD activity leading to a release of choline that could be used for ACh synthesis.
Previous studies have shown that choline derived from PC is indeed used for ACh synthesis [ 4 14 15 16 ] and that this choline is generated by a PLD [ 4 14 ] . This pathway may become particularly important when extracellular circulating choline concentrations are low (e.g.