Example sentences for: ach

How can you use “ach” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The synthesis of the neurotransmitter acetylcholine (ACh) 1in cholinergic neurons is dependent on the availability of its precursor, choline, most of which is derived from the circulation (reviewed in [ 1 ] ) and enters cholinergic neurons via a process catalyzed by a specific transporter [ 2 3 ] . Some of the choline used for ACh synthesis is stored in membrane phosphatidylcholine (PC).

  • Most of the previous studies on the physiological functions PLDs have concentrated on the role of its product, PA [ 7 ] . Our data show that PLD has a dual function in cholinergic cells, as the second product of its activity, choline, is used as a metabolic precursor of ACh, and suggest that this pathway may be regulated by the type of PLD isoform expressed in a particular class of cholinergic neurons.

  • Significantly, intracellular choline and ACh content were similarly decreased by the antisense oligonucleotides, indicating that PLD2-catalyzed hydrolysis of PC provides choline for ACh synthesis.

  • Thus, while the catalytic activities of both PLD1 and PLD2 appear to be equivalent in generating choline for ACh synthesis in transfected cells, it is possible that the modes of regulation of their activity might specify which one is expressed in a particular population of cholinergic neurons in vivo.

  • For example, despite the fact that insulin did not inhibit Ach receptor signaling in our experiment, the rat M1 Ach receptor contains several MAP kinase sites, including one Thr-Pro sequence in the 2 ndintracellular loop and 3 Ser-Pro and one Thr-Pro in the 3 rdintracellular loop.


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