Example sentences for: ach

How can you use “ach” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In control studies performed in the presence of choline (15 μM) in the medium PMA had no effect on ACh levels (data not shown), indicating that it did not stimulate the process of ACh synthesis but only the supply of choline.

  • In the center of this region is a critical glycine residue that is thought to play a role in establishing a hairpin loop [ 12 ] . Recent x-ray crystallographic data obtained from an ACh binding protein (AChBP) shows a loop structure in this region resulting from a 3 residue turn containing a glycine homologous to G147 of the 5-HT 3 R. On either side of this putative turn region are residues that have been identified as important to receptor binding [ 12 13 14 15 16 17 18 ] . The formation of this loop structure brings amino acids on either side of glycine into close proximity and may form a binding pocket that will accommodate one or more functional groups.

  • Although it is clear that the PLD-generated choline is efficiently utilized by cholinergic cells (LA-N-2 and SN56) as a precursor of ACh, the quantitative significance of this pathway and mechanisms that regulate it remain to be fully determined.

  • during dietary choline deficiency) or when ACh synthesis and release are accelerated by high neuronal activity, thus generating a high demand for choline [ 16 ] .

  • 1ACh, acetylcholine; ARF, ADP-ribosylation factor; DAG, diacylglycerol; G3PDH, glyceraldehyde 3-phosphate dehydrogenase; MAChR, muscarinic acetylcholine receptor; PA, phosphatidic acid; PC, phosphatidylcholine; PIP 2 , phosphatidylinositol 4, 5-bisphosphate; PKC, protein kinase C; PLD, phospholipase D; PMA, phorbol 12-myristate 13-acetate; PP, phosphatidylpropanol; ROS, reactive oxygen species; TLC, thin layer chromatography.


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