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Example sentences for: achr
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That the correlation coefficient never approaches unity is also consistent with the previous work - in general it has been found that AChR aggregates contain α-DG, but visible concentrations of α-DG can be found in the absence of AChRs.
Again in agreement with AChR observations, α-DG aggregate density is increased by LN1 but not agrin (Figure 4D) - however in this case it appears that this increase is prevented by agrin, while in the case of AChRs the combination follows the LN1 alone phenotype of increased aggregate density.
Figure 3) that there is less perfect colocalization of α-DG within AChR aggregates in the present study than reported previously (see for example [ 4 ] Figure 9 for a comparable study using Xenopus muscle cell cultures).
[ 5 ] . BDNF transiently stabilizes silent NM synapses during the period of transition from polyneuronal to mononeuronal innervation of skeletal muscle fibers [ 6 ] . BDNF and CNTF cooperatively affect efficiency of embryonic xenopus neuromuscular synapses in culture [ 7 8 ] . BDNF stimulates transmitter release from neuromuscular synapses [ 9 ] and enhances the efficiency of transmission at the neuromuscular synapse [ 10 ] . BDNF, together with NT-3, can restore neuregulin levels and a normal distribution of AchR at the neuromuscular junction blocked with curare [ 11 ] . BDNF, in conjunction with fibronectin, increases spontaneous synaptic currents in the cultured embryonic xenopus neuromuscular junction [ 12 ] . BDNF down-regulates AchR clustering, most likely by binding to TrkB expressed in myocytes [ 13 ] . BDNF downregulates agrin levels in muscle but increases neuregulin in ventral horn spinal motor neurons at the time when they form neuromuscular synapses [ 14 ] .
Taken together these observations have led to the hypothesis that LN1 serves as a secondary or supporting stimulus for agrin induced AChR aggregation [ 1 2 24 ] . The present study is directed at a quantitative examination of the interaction between the signal transduction pathways for agrin and LN1 induction of AChR aggregates and colocalized α-DG aggregates.
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