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Example sentences for: achr
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Again in agreement with AChR observations, α-DG aggregate density is increased by LN1 but not agrin (Figure 4D) - however in this case it appears that this increase is prevented by agrin, while in the case of AChRs the combination follows the LN1 alone phenotype of increased aggregate density.
Taken together these observations have led to the hypothesis that LN1 serves as a secondary or supporting stimulus for agrin induced AChR aggregation [ 1 2 24 ] . The present study is directed at a quantitative examination of the interaction between the signal transduction pathways for agrin and LN1 induction of AChR aggregates and colocalized α-DG aggregates.
Mutagenesis studies have identified the interaction of amino acids W89 and R91 in the binding of 5-HT 3 R ligands [ 24 23 ] . Studies conducted in our laboratory have identified three additional putative binding site residues (Y140, Y142, and Y152) [ 25 ] . W89 and R91 are present in a conserved region of LGIC receptors often referred to as loop D [ 24 26 ] . Similarly, Y140, Y142 and Y152 are located in the region homologus to E loop region of nicotinic AchR.
Figure 3) that there is less perfect colocalization of α-DG within AChR aggregates in the present study than reported previously (see for example [ 4 ] Figure 9 for a comparable study using Xenopus muscle cell cultures).
Thus there appears to be a "one way correlation"; whether the stimulus is agrin or laminin AChR aggregation is an excellent predictor of α-DG aggregation, but the converse is not found (see particularly [ 4 ] ). This lack of reciprocity will of course reduce the label correlation as measured in the present study.
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