Example sentences for: achr

How can you use “achr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 5 ] . BDNF transiently stabilizes silent NM synapses during the period of transition from polyneuronal to mononeuronal innervation of skeletal muscle fibers [ 6 ] . BDNF and CNTF cooperatively affect efficiency of embryonic xenopus neuromuscular synapses in culture [ 7 8 ] . BDNF stimulates transmitter release from neuromuscular synapses [ 9 ] and enhances the efficiency of transmission at the neuromuscular synapse [ 10 ] . BDNF, together with NT-3, can restore neuregulin levels and a normal distribution of AchR at the neuromuscular junction blocked with curare [ 11 ] . BDNF, in conjunction with fibronectin, increases spontaneous synaptic currents in the cultured embryonic xenopus neuromuscular junction [ 12 ] . BDNF down-regulates AchR clustering, most likely by binding to TrkB expressed in myocytes [ 13 ] . BDNF downregulates agrin levels in muscle but increases neuregulin in ventral horn spinal motor neurons at the time when they form neuromuscular synapses [ 14 ] .

  • Taken together these observations have led to the hypothesis that LN1 serves as a secondary or supporting stimulus for agrin induced AChR aggregation [ 1 2 24 ] . The present study is directed at a quantitative examination of the interaction between the signal transduction pathways for agrin and LN1 induction of AChR aggregates and colocalized α-DG aggregates.

  • Quantitative analyses of the α-DG distributions are summarized in Figure 4(the observed AChR aggregates were consistent with the observations presented above but were not pooled with those data because they were not performed on matching sister cultures).

  • That the correlation coefficient never approaches unity is also consistent with the previous work - in general it has been found that AChR aggregates contain α-DG, but visible concentrations of α-DG can be found in the absence of AChRs.

  • Mutagenesis studies have identified the interaction of amino acids W89 and R91 in the binding of 5-HT 3 R ligands [ 24 23 ] . Studies conducted in our laboratory have identified three additional putative binding site residues (Y140, Y142, and Y152) [ 25 ] . W89 and R91 are present in a conserved region of LGIC receptors often referred to as loop D [ 24 26 ] . Similarly, Y140, Y142 and Y152 are located in the region homologus to E loop region of nicotinic AchR.


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