Words similar to achrs
Example sentences for: achrs
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Again in agreement with AChR observations, α-DG aggregate density is increased by LN1 but not agrin (Figure 4D) - however in this case it appears that this increase is prevented by agrin, while in the case of AChRs the combination follows the LN1 alone phenotype of increased aggregate density.
Laminins are major components of the extracellular matrix and exist in many isoforms with varying functions including cell adhesion, neurite outgrowth, and cellular signaling [ 7 8 9 10 ] . Laminin binds agrin [ 11 ] , and colocalizes with AChR aggregates [ 12 13 14 ] . It also binds with α-Dystroglycan (α-DG), an important part of the dystrophin/utrophin glycoprotein complex (Reviewed in [ 15 16 ] ). The dystrophin complex is also found concentrated at the neuromuscular junction with AChRs and laminin, and for this and other reasons is thought to be involved in both formation and maintenance of the NMJ [ 2 17 18 19 20 21 22 23 ] .
Increased expression of AChRs could decrease the dissolution of aggregates, thereby increasing aggregate size, density, and (over time) number.
Also, while laminin stimulation increased the colocalization of AChRs and αDG in our experiments, agrin also produced a similar increase (Figure 5).
Accordingly the question arises as to how this approach can be compared with previous studies which demonstrate a visible colocalization of AChRs and α-DG in muscle cells stimulated by nerve terminals [ 19 ] or agrin [ 4 20 26 27 ] . First we note that the present results do support a significant colocalization of the two molecules in agrin stimulated cells as compared to controls (Figure 5), in general agreement with previous findings.
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