Words similar to achrs
Example sentences for: achrs
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That the correlation coefficient never approaches unity is also consistent with the previous work - in general it has been found that AChR aggregates contain α-DG, but visible concentrations of α-DG can be found in the absence of AChRs.
Accordingly the question arises as to how this approach can be compared with previous studies which demonstrate a visible colocalization of AChRs and α-DG in muscle cells stimulated by nerve terminals [ 19 ] or agrin [ 4 20 26 27 ] . First we note that the present results do support a significant colocalization of the two molecules in agrin stimulated cells as compared to controls (Figure 5), in general agreement with previous findings.
Laminins are major components of the extracellular matrix and exist in many isoforms with varying functions including cell adhesion, neurite outgrowth, and cellular signaling [ 7 8 9 10 ] . Laminin binds agrin [ 11 ] , and colocalizes with AChR aggregates [ 12 13 14 ] . It also binds with α-Dystroglycan (α-DG), an important part of the dystrophin/utrophin glycoprotein complex (Reviewed in [ 15 16 ] ). The dystrophin complex is also found concentrated at the neuromuscular junction with AChRs and laminin, and for this and other reasons is thought to be involved in both formation and maintenance of the NMJ [ 2 17 18 19 20 21 22 23 ] .
AChRs were labeled with rhodamine (single label experiments) or fluorescein (double label experiments) conjugated αBGT (300 nM, Molecular Probes, T-1175/T-1176), and α-DG with a monoclonal antibody (1:1000, Upstate Biotechnology, 05-298, 45 minutes) followed by a secondary antibody (Rhodamine-Goat anti-mouse IgG, 1:100, Jackson Immuno Research Laboratories, 115-025-003, 45 minutes).
Increased expression of AChRs could decrease the dissolution of aggregates, thereby increasing aggregate size, density, and (over time) number.
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