Words similar to achbp
Example sentences for: achbp
How can you use “achbp” in a sentence? Here are some example sentences to help you improve your vocabulary:
Surprisingly, the ester moiety of acetylcholine does not seem to interact with the cys-loop of the receptor, as previously suggested by photoaffinity labeling [ 12 ] , but is engaged in similar type of interaction as that observed with the acidic group of HEPES in the AChBP crystal structure [ 6 ] . It is possible that the reactive di-azo group of the photosensitive agonist used in photoaffinity labeling would extend towards the cys-loop, while the conformation of the bound agonist remains in agreement with our model.
For example, amino acids homologous to Y142 and W183 (R104 and W143 respectively) are in close proximity in the AChBP, although on complementary faces of the receptor subunits [ 24 ] . Spier et.
These amino acids form a cluster in the proposed acetylcholine binding domain of AChBP similar to that proposed in our model.
The interaction is included in the model based on structural information obtained from the crystal structure of AChBP [ 27 ] . The region of this protein homologous to loop E and loop D of the 5-HT 3A receptor suggests a loop structure from Y140 to Y152 and a 3-residue turn containing a glycine at position 147 and the β-strand from W89 through Y93 oriented as shown in Figure 6. The orientation of lerisetron between W89 and Y142A as shown would enable the N-benzyl group to be positioned in close proximity to R91.
[ 6 ] that differed from the AChBP template residue were energy-minimized in the internal coordinates space using ICM global conformational search algorithm.
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