Example sentences for: achbp

How can you use “achbp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • R91, E106, F107, W183 and several residues adjacent to the M1 region have all been demonstrated to alter the action of 5-HT and/or m CPBG [ 20 21 25 26 ] . Within the crystal structure of the AChBP, homologous residues are located in the apparent binding site [ 24 ] . The effects of agonist on the 5-HT 3 R are mediated by their interaction with these binding site residues, resulting in stable receptor conformations, including the channel open state.

  • In addition, our data support the existence of a loop structure in this region as has been hypothesized for the nAChR and identified in a homologous AChBP [ 12 23 24 ] .

  • In the center of this region is a critical glycine residue that is thought to play a role in establishing a hairpin loop [ 12 ] . Recent x-ray crystallographic data obtained from an ACh binding protein (AChBP) shows a loop structure in this region resulting from a 3 residue turn containing a glycine homologous to G147 of the 5-HT 3 R. On either side of this putative turn region are residues that have been identified as important to receptor binding [ 12 13 14 15 16 17 18 ] . The formation of this loop structure brings amino acids on either side of glycine into close proximity and may form a binding pocket that will accommodate one or more functional groups.

  • These amino acids form a cluster in the proposed acetylcholine binding domain of AChBP similar to that proposed in our model.

  • This binding site coincides with that of AChBP, and is in agreement with photo-affinity labeling and mutagenesis study [ 6 11 ] . The ligand makes Van der Waals contact with Trp182, Tyr230 and Cys225-226 of alpha4, and Trp82, Leu146 and Phe144 of beta2 (Figure 3- Top).

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