Example sentences for: achbp

How can you use “achbp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The crystal structure of two consecutive AChBP monomers [ 6 ] was used as a template to build a homology-model of four known native human nAChR subunit interfaces: alpha4-beta2 (I1), alpha4-beta4 (I2), alpha3-beta2 (I3), and alpha7-alpha7 (I4).

  • [ 6 ] that differed from the AChBP template residue were energy-minimized in the internal coordinates space using ICM global conformational search algorithm.

  • All residues in the close vicinity of this ligand were confirmed experimentally as being part of the acetylcholine binding pocket [ 6 ] . While the homology between AChBP and the nAChR subunits is relatively low (22 % sequence identity, for instance, between alpha4 and AChBP), and the overall model needs to be refined, 72% of the AChBP residues in contact with HEPES are identical in the alpha4-beta2 nAChR (Figure 1), and the predicted conformation of the agonist binding pocket of nAChR is expected to be accurate.

  • The model for lerisetron binding will be further refined as its interactions with other binding site amino acids are investigated [ 26 32 33 ] . Of particular interest would be potential interactions of the N-benzyl group that would account for the decrease in binding affinity of analog 2. Additional information gained from comparison of our model with the recent crystal structure of the AChBP demonstrates that lerisetron can be roughly 'fit' into the binding site such that all the residues line up as shown in our model.

  • To address further the specificity of this ligand candidate, we docked it, as previously described, to the other three nAChRs subtypes studied in this work, as well as to the crystal structure of AChBP, and calculated the corresponding binding energies (Table 1bottom).


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