Words similar to achbp
Example sentences for: achbp
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R91, E106, F107, W183 and several residues adjacent to the M1 region have all been demonstrated to alter the action of 5-HT and/or m CPBG [ 20 21 25 26 ] . Within the crystal structure of the AChBP, homologous residues are located in the apparent binding site [ 24 ] . The effects of agonist on the 5-HT 3 R are mediated by their interaction with these binding site residues, resulting in stable receptor conformations, including the channel open state.
The amino acids W89, R91 Y140, Y142 and Y152 of the 5HT 3 A R can be aligned with W53, Q55, L102, R104, and M114 of the AChBP (Figure 6).
Again, the predicted energies of acetylcholine and nicotine binding to AChBP are close to those for binding to nAChRs (Table 1- top).
Low-energy conformations were found only in the absence of water molecule, and the calculated binding energies (Table 1- bottom) suggest that HEPES is a poor ligand for nAChRs, and AChBP, and was observed in the crystal structure because of its high concentration (100 mM) in the crystallization condition [ 6 ] .
The model for lerisetron binding will be further refined as its interactions with other binding site amino acids are investigated [ 26 32 33 ] . Of particular interest would be potential interactions of the N-benzyl group that would account for the decrease in binding affinity of analog 2. Additional information gained from comparison of our model with the recent crystal structure of the AChBP demonstrates that lerisetron can be roughly 'fit' into the binding site such that all the residues line up as shown in our model.
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