Example sentences for: achbp

How can you use “achbp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Surprisingly, the ester moiety of acetylcholine does not seem to interact with the cys-loop of the receptor, as previously suggested by photoaffinity labeling [ 12 ] , but is engaged in similar type of interaction as that observed with the acidic group of HEPES in the AChBP crystal structure [ 6 ] . It is possible that the reactive di-azo group of the photosensitive agonist used in photoaffinity labeling would extend towards the cys-loop, while the conformation of the bound agonist remains in agreement with our model.

  • For example, amino acids homologous to Y142 and W183 (R104 and W143 respectively) are in close proximity in the AChBP, although on complementary faces of the receptor subunits [ 24 ] . Spier et.

  • These amino acids form a cluster in the proposed acetylcholine binding domain of AChBP similar to that proposed in our model.

  • The interaction is included in the model based on structural information obtained from the crystal structure of AChBP [ 27 ] . The region of this protein homologous to loop E and loop D of the 5-HT 3A receptor suggests a loop structure from Y140 to Y152 and a 3-residue turn containing a glycine at position 147 and the β-strand from W89 through Y93 oriented as shown in Figure 6. The orientation of lerisetron between W89 and Y142A as shown would enable the N-benzyl group to be positioned in close proximity to R91.

  • [ 6 ] that differed from the AChBP template residue were energy-minimized in the internal coordinates space using ICM global conformational search algorithm.


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