Words similar to acetylcholine
Example sentences for: acetylcholine
How can you use “acetylcholine” in a sentence? Here are some example sentences to help you improve your vocabulary:
5-HT 4 receptor (Htr4 transcript) increases in expression have been shown to augment hippocampal acetylcholine outflow, thereby affecting cognitive processes [ 85 ] .
Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.
The protonated ammonium nitrogen is also making polar interaction with the delocalized electron and backbone carbonyl of Trp182, and is less than 1A away from the quaternary nitrogen of docked acetylcholine.
Again, the predicted energies of acetylcholine and nicotine binding to AChBP are close to those for binding to nAChRs (Table 1- top).
Mutation of the homologous residue in the GABA A receptor γ-subunit (T142) to serine altered the efficacy of the agonist Flumazenil, converting it to a partial agonist [ 29 ] . In the nAChR, mutation of mouse and rat εP121 to leucine altered both the binding of acetylcholine and the stability of the open state of the channel.
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