Example sentences for: acetylcholine

How can you use “acetylcholine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 1) It is the 16 thbest scoring compound, and displays better calculated binding energies than acetylcholine or nicotine for alpha4-beta2 nAChR (Table 1- Bottom).

  • Abnormalities of the peripheral vasculature responses to acetylcholine have been previously described in Fabry disease together with nitric oxide pathway dysregulation [ 5 9 ] suggesting participation of non-NO regulation of vascular tone.

  • This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.

  • Classical neurotransmitter receptors such as muscarinic acetylcholine receptors (mAChR), adrenergic, dopaminergic, serotoninergic as well as neuropeptide receptors belong to this family ( 1).

  • A previous report using immunofluorescence demonstrated colocalization of RIα with the nicotinic acetylcholine receptor (nAChR) at the NMJ postsynaptic membrane [ 19 ] . We used immunohistochemistry coupled with confocal microscopy to acquire detailed information as to the intracellular localization of D-AKAP1 in the several regions of the NMJ and adjacent intercostal muscle to compare with that of RIα.


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