Words similar to acetylcholine
Example sentences for: acetylcholine
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This is in agreement with previous work assigning a cation-pi interaction between acetylcholine and this residue exclusively [ 9 ] . The carbonyl oxygen of acetylcholine and backbone nitrogen of Leul46 are also engaged in a hydrogen bond.
Distinct nAChR subtypes exist that can be stimulated by the neurotransmitter acetylcholine, the natural product nicotine, or by synthetic compounds [ 1 ] . nAChR is the prototype for a protein superfamily that includes the receptors for the excitatory amino acids glutamate and aspartate, the inhibitory amino-acids gamma-aminobutyric acid (GABA) and glycine, as well as the serotonin 5-HT 3 receptor [ 1 ] . Like most ligand-gated ion channels, nAChRs are homo- or hetero-pentameric, each monomer belonging to a pull of 8 alpha- or 3 beta-subunits (alpha 2-9 , beta 2-4 ). While each subunit has four transmembrane domains, the agonist binding sites are located at the subunit interfaces [ 2 ] . Both natural and synthetic ligands can display varied affinity for different receptor subtypes.
All residues in the close vicinity of this ligand were confirmed experimentally as being part of the acetylcholine binding pocket [ 6 ] . While the homology between AChBP and the nAChR subunits is relatively low (22 % sequence identity, for instance, between alpha4 and AChBP), and the overall model needs to be refined, 72% of the AChBP residues in contact with HEPES are identical in the alpha4-beta2 nAChR (Figure 1), and the predicted conformation of the agonist binding pocket of nAChR is expected to be accurate.
Acetylcholine and histamine are important in the vestibular apparatus.
Oocytes were injected with in vitro transcribed RNA for the mouse 5-HT 2C [ 50 ] and the M1 acetylcholine (kindly provided by Dr. T. Bonner) receptors for the experiment in Fig.
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