Example sentences for: acetylcholine

How can you use “acetylcholine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This is in agreement with previous work assigning a cation-pi interaction between acetylcholine and this residue exclusively [ 9 ] . The carbonyl oxygen of acetylcholine and backbone nitrogen of Leul46 are also engaged in a hydrogen bond.

  • Distinct nAChR subtypes exist that can be stimulated by the neurotransmitter acetylcholine, the natural product nicotine, or by synthetic compounds [ 1 ] . nAChR is the prototype for a protein superfamily that includes the receptors for the excitatory amino acids glutamate and aspartate, the inhibitory amino-acids gamma-aminobutyric acid (GABA) and glycine, as well as the serotonin 5-HT 3 receptor [ 1 ] . Like most ligand-gated ion channels, nAChRs are homo- or hetero-pentameric, each monomer belonging to a pull of 8 alpha- or 3 beta-subunits (alpha 2-9 , beta 2-4 ). While each subunit has four transmembrane domains, the agonist binding sites are located at the subunit interfaces [ 2 ] . Both natural and synthetic ligands can display varied affinity for different receptor subtypes.

  • All residues in the close vicinity of this ligand were confirmed experimentally as being part of the acetylcholine binding pocket [ 6 ] . While the homology between AChBP and the nAChR subunits is relatively low (22 % sequence identity, for instance, between alpha4 and AChBP), and the overall model needs to be refined, 72% of the AChBP residues in contact with HEPES are identical in the alpha4-beta2 nAChR (Figure 1), and the predicted conformation of the agonist binding pocket of nAChR is expected to be accurate.

  • Acetylcholine and histamine are important in the vestibular apparatus.

  • Oocytes were injected with in vitro transcribed RNA for the mouse 5-HT 2C [ 50 ] and the M1 acetylcholine (kindly provided by Dr. T. Bonner) receptors for the experiment in Fig.


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