Words similar to acetylcholine
Example sentences for: acetylcholine
How can you use “acetylcholine” in a sentence? Here are some example sentences to help you improve your vocabulary:
1) It is the 16 thbest scoring compound, and displays better calculated binding energies than acetylcholine or nicotine for alpha4-beta2 nAChR (Table 1- Bottom).
Abnormalities of the peripheral vasculature responses to acetylcholine have been previously described in Fabry disease together with nitric oxide pathway dysregulation [ 5 9 ] suggesting participation of non-NO regulation of vascular tone.
This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.
Classical neurotransmitter receptors such as muscarinic acetylcholine receptors (mAChR), adrenergic, dopaminergic, serotoninergic as well as neuropeptide receptors belong to this family ( 1).
A previous report using immunofluorescence demonstrated colocalization of RIα with the nicotinic acetylcholine receptor (nAChR) at the NMJ postsynaptic membrane [ 19 ] . We used immunohistochemistry coupled with confocal microscopy to acquire detailed information as to the intracellular localization of D-AKAP1 in the several regions of the NMJ and adjacent intercostal muscle to compare with that of RIα.
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