Example sentences for: acetylcholine

How can you use “acetylcholine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Sequence homology between the serotonin type 3 receptor (5-HT 3 R), the nicotinic acetylcholine receptor (nAChR), the GABA A receptor and the glycine receptor suggests a large amount of structural similarity within this superfamily of ligand gated ion channels [ 1 2 3 ] . This presumed structural homology can be used to guide site directed mutagenesis studies of particular receptor subtypes.

  • In all cases, the predicted binding energies are better than for nicotine or acetylcholine.

  • Acetylcholine fits tightly into the agonist binding site at the alpha4-beta2 interface of nAChR (Figure 2).

  • Indeed, a correlation between EC50 values and quantum mechanics simulations strongly suggests the existence of a cation-pi interaction between a triptophan residue of the ligand binding pocket and the quaternary ammonium of acetylcholine [ 9 ] . A series of grid representations of the ligand binding pocket was generated that accounted for Van der Waals shape, electrostatic potential, as well as hydrogen bonding and hydrophobicity profiles.

  • A previous report using immunofluorescence demonstrated colocalization of RIα with the nicotinic acetylcholine receptor (nAChR) at the NMJ postsynaptic membrane [ 19 ] . We used immunohistochemistry coupled with confocal microscopy to acquire detailed information as to the intracellular localization of D-AKAP1 in the several regions of the NMJ and adjacent intercostal muscle to compare with that of RIα.


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