Words similar to acetylation
Example sentences for: acetylation
How can you use “acetylation” in a sentence? Here are some example sentences to help you improve your vocabulary:
RAR/RXR binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [ 3 4 ] . Ligand binding displaces the repressors and recruits coactivator proteins such as CBP which have histone acetyltransferase activity [ 5 ] . Histone acetylation allows for chromatin unwinding and transcriptional initiation of target gene expression [ 6 ] .
Other epigenetic mechanisms involving defects in chromatin modification factors such as the association of methyl-CpG binding proteins, acetylation and methylation of histone proteins are also becoming known [ 15 ] . The role of these chromatin-mediated components in inactivating the MGMT gene remains to be examined in GCT.
A highly ordered chromatin structure presents a physical obstacle for gene transcription; presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] . In concert with the observation that corepressors are associated with HDAC activities [ 84 85 ] , it appears that the transcriptional outcome of nuclear receptors is determined by the balance of histone acetylation and deacetylation activities, and that ligands serve as a switch to recruit HATs with the concomitant dismissal of HDACs.
We focused on H3 and H4 because antibodies are available and acetylation events in those histones have been studied.
These data, therefore, suggest that other epigenetic mechanisms involving defects in chromatin modification factors such as acetylation and methylation of histone proteins may also play role in gene silencing.
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