Example sentences for: acetylation

How can you use “acetylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is noteworthy that the mechanism of SAHA in G1 cell growth arrest may target the expression of specific proteins involved in DNA synthesis as it inhibited E2F-1 and PCNA, but not E2F-4, suggesting that SAHA may cause different levels of histone acetylation at distinct regions of the genome.

  • Although SAHA increases acetylation of histones H3 and H4, it is not known whether SAHA is able to inhibit all HDAC activities of all types of histones, including HDAC1, or whether the profound increase in Rb2/p130-E2F-4 nuclear complex after SAHA treatment may have an alternative pathway other than recruitment of HDAC1 activity.

  • These data, therefore, suggest that other epigenetic mechanisms involving defects in chromatin modification factors such as acetylation and methylation of histone proteins may also play role in gene silencing.

  • Recent studies demonstrated acetylation of p53 in the C-terminal domain increased the DNA-binding capacity of the protein [ 53, 54, 55].

  • We focused on H3 and H4 because antibodies are available and acetylation events in those histones have been studied.


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