Example sentences for: acetylation

How can you use “acetylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These data, therefore, suggest that other epigenetic mechanisms involving defects in chromatin modification factors such as acetylation and methylation of histone proteins may also play role in gene silencing.

  • SAHA was able to increase histone H3 and H4 protein and acetylation levels, and caused a profound decrease in the protein levels of key molecules, PCNA and E2F-1, essential for DNA synthesis.

  • No differences in histone H3 and H4 acetylation levels were, however, observed in relation to p53 status between the two cell lines.

  • Although SAHA increases acetylation of histones H3 and H4, it is not known whether SAHA is able to inhibit all HDAC activities of all types of histones, including HDAC1, or whether the profound increase in Rb2/p130-E2F-4 nuclear complex after SAHA treatment may have an alternative pathway other than recruitment of HDAC1 activity.

  • Recent studies demonstrated acetylation of p53 in the C-terminal domain increased the DNA-binding capacity of the protein [ 53, 54, 55].


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