Example sentences for: acetylation

How can you use “acetylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Other epigenetic mechanisms involving defects in chromatin modification factors such as the association of methyl-CpG binding proteins, acetylation and methylation of histone proteins are also becoming known [ 15 ] . The role of these chromatin-mediated components in inactivating the MGMT gene remains to be examined in GCT.

  • Both severe hepatitis and acute liver failure have been attributed to SSZ [ 25 26 27 28 ] . Patients with SSZ hepatotoxicity demonstrate a prompt recurrence of symptoms upon rechallenge with SSZ or sulfonamide [ 15 29 30 31 ] . Susceptibility to the toxic effects of SSZ and other sulfonamides may be due to the interaction of metabolic pathways regulating N-acetylation and specific detoxification of the metabolites of the drug [ 32 33 ] . However, it remains unclear if genetic differences in drug metabolizing enzyme expression may increase the risk of SSZ toxicity.

  • It is noteworthy that the mechanism of SAHA in G1 cell growth arrest may target the expression of specific proteins involved in DNA synthesis as it inhibited E2F-1 and PCNA, but not E2F-4, suggesting that SAHA may cause different levels of histone acetylation at distinct regions of the genome.

  • Although SAHA increases acetylation of histones H3 and H4, it is not known whether SAHA is able to inhibit all HDAC activities of all types of histones, including HDAC1, or whether the profound increase in Rb2/p130-E2F-4 nuclear complex after SAHA treatment may have an alternative pathway other than recruitment of HDAC1 activity.

  • We did not, however, observe differences in the initial acetylation levels between untreated TM10 and TM2H cell lines.


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