Example sentences for: acv

How can you use “acv” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The proportions of virus resistant to ACV or PCV, which arise during amplification of virus stocks in the absence of drug selection, were measured by the method described by Hall et al.

  • These results were confirmed when the same isolates were tested for susceptibility to ACV (results not shown) and all the IC 50 s were sensitive over a similar range as PCV.

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.

  • The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .

  • 40% ACV rand 0.13-0.


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