Example sentences for: acv

How can you use “acv” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Interestingly, although 14-P4 was resistant, the third pass isolate for this sample was completely sensitive to both antiviral agents (ACV IC 50 = 0.16 μg/ml; PCV IC 50 = 0.53 μg/ml).

  • Furthermore, the resulting virus preparation from subsequent passaging of 14-P4 reverted to a sensitive phenotype (ACV IC 50 = 0.74 μg/ml; PCV IC 50 = 0.74 μg/ml), although suboptimal treatment was still utilized.

  • The former is widely accepted as the gold standard for susceptibility testing of HSV, and for ACV, a correlation between PRA in vitro IC 50 and clinical outcome has been established.

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.

  • Resistance to acyclovir (ACV) or penciclovir (PCV) generally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [ 5 ] ]. Unlike Pol, TK is not essential for virus replication in cell culture [ 7 ] , although in vivo analyses implicate it in HSV virulence, pathogenicity and reactivation from latency [ 4 8 16 22 ] . Since ACV and PCV are dependent upon HSV TK for monophosphorylation, an event obligatory for the formation of the active triphosphate inhibitor [ 14 ] , ACV risolates often exhibit high levels of cross-resistance to PCV [ 2 3 ] .


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