Example sentences for: acv

How can you use “acv” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .

  • ACV used in these studies was obtained from Sigma (St.

  • [ 9 ] demonstrated sequential HSV inoculation from mouse to mouse receiving sub-optimal ACV therapy led to the selection and amplification of resistant virus in vivo.

  • [ 10 ] . Plating efficiency assays were performed in MRC-5 cells at 3 μg/ml ACV, which is 10-times higher than the average IC 50 for HSV-1 SVC16, and at 8 μg/ml ACV, which is 10-times higher than the average IC 50 for the panel of HSV-2 viruses.

  • These observations can not be accounted for by differences in exposure to ACV and PCV since oral administration of VCV and FCV results in almost identical blood concentration-time curves for ACV and PCV [ 11 ] . A more probable explanation is that ACV is approximately four-fold more potent than PCV in murine cells [ 21 ] .


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