Words similar to tcf
Example sentences for: tcf
How can you use “tcf” in a sentence? Here are some example sentences to help you improve your vocabulary:
In initial experiments, we found that Wnt-3A protein elevates the levels of β-catenin 5-10 fold (Figure 4); and that a transiently transfected TCF reporter construct is activated 3-4 fold (not shown).
The algorithm described above was applied to a microarray experiment designed to compare gene expression in human cells harboring either a cadherin-derived inhibitor (Cad5CD) of the β-catenin pathway, or a dominant-negative Tcf inhibitor (TcfDN) of the pathway [ 7 8 ] . The biological interpretation of the results will be presented elsewhere (Pierce and Kamb, unpublished).
In the Wnt target gene promoters that are functionally mapped (MSX1, MSX2, ID2, ID3, Follistatin, REST/NRSF, Versican) we invariably found TCF binding sites.
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.
aa, amino acid; Ab, antibody; bp, base pair; CaPO 4 , calcium phosphate; C/EBPβ, CCAAT-enhancer binding protein-beta; CAT, chloramphenicol acetyl transferase; DMEM, Dulbecco's Modified Eagle Medium; GST, glutathione-S-transferase; MAPK, mitogen activated protein kinase; PBS, phosphate buffered saline; PMSF, phenylmethylsulfonyl fluoride; SRE, serum response element; SRF, serum response factor; TCF, ternary complex factor.
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