Words similar to tcf
Example sentences for: tcf
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ID2 was recently shown also to be a target of activated β-catenin in colon carcinoma cells [ 13 ] . It is a general inhibitor of the bHLH proteins such as MyoD and E12/E47 [ 14 ] and can interact with the tumor suppressor RB1 [ 15 ] . MSX1 expression can revert differentiated myotubes into an undifferentiated state [ 16 ] . REST/NRSF is known to block neural differentiation by binding to and inhibiting the expression of neuronal genes [ 17 18 ] . To what extent these genes are controlled by Wnt signaling in intact animals or in other cell types is not clear yet, but we do note that MSX mutants have phenotypes similar to LEF/TCF mutants [ 19 20 ] .
We have not directly tested the ability of the other TCF famlily members, SAP1 and SAP2/ERP/NET, to interact with C/EBPβ.
We find that the domain of Elk-1 that interacts with C/EBPβ is the ets domain, which is conserved among the other TCF family members [ 16].
This developmentally important pathway contains several proteins, including APC, Frizzled, Axin and GSK3, which act in concert to promote the proteosomal degradation of β-catenin [ 13 14 ] . When APC is rendered inactive by mutation, β-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .
To this point, the TCF family members have been thought to be the main targets of Ras signaling to the SRE, and activation of TCF by Ras has been shown to result in transactivation of the SRE [ 16].
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