Words similar to tcf
Example sentences for: tcf
How can you use “tcf” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, transcription factor 8 (TCF8) can repress interleukin 2 (IL2) expression by binding to a negative regulatory element 100 bp upstream of the IL2 transcription start site [ 15].
The algorithm described above was applied to a microarray experiment designed to compare gene expression in human cells harboring either a cadherin-derived inhibitor (Cad5CD) of the β-catenin pathway, or a dominant-negative Tcf inhibitor (TcfDN) of the pathway [ 7 8 ] . The biological interpretation of the results will be presented elsewhere (Pierce and Kamb, unpublished).
ID2 was recently shown also to be a target of activated β-catenin in colon carcinoma cells [ 13 ] . It is a general inhibitor of the bHLH proteins such as MyoD and E12/E47 [ 14 ] and can interact with the tumor suppressor RB1 [ 15 ] . MSX1 expression can revert differentiated myotubes into an undifferentiated state [ 16 ] . REST/NRSF is known to block neural differentiation by binding to and inhibiting the expression of neuronal genes [ 17 18 ] . To what extent these genes are controlled by Wnt signaling in intact animals or in other cell types is not clear yet, but we do note that MSX mutants have phenotypes similar to LEF/TCF mutants [ 19 20 ] .
However, we show that Ras activation of TCF alone does not result in maximal SRE transactivation, but instead, is greatly enhanced in the presence of p35-C/EBPβ.
In considering these issues, it is of interest to note that in the early C. elegans embryo, Wnt signaling proceeds through a non-canonical pathway, through phosphorylation of the TCF homolog but not using the increase in β-catenin [ 33 ] . Cell divisions and polarization in the worm embryo occur on a time scale of minutes, and the different mechanism of Wnt signaling in that context may be more suitable than the inherently slower translation-dependent β-catenin increase.
Loading...