Words similar to tcf
Example sentences for: tcf
How can you use “tcf” in a sentence? Here are some example sentences to help you improve your vocabulary:
We find that the domain of Elk-1 that interacts with C/EBPβ is the ets domain, which is conserved among the other TCF family members [ 16].
The algorithm described above was applied to a microarray experiment designed to compare gene expression in human cells harboring either a cadherin-derived inhibitor (Cad5CD) of the β-catenin pathway, or a dominant-negative Tcf inhibitor (TcfDN) of the pathway [ 7 8 ] . The biological interpretation of the results will be presented elsewhere (Pierce and Kamb, unpublished).
ID2 was recently shown also to be a target of activated β-catenin in colon carcinoma cells [ 13 ] . It is a general inhibitor of the bHLH proteins such as MyoD and E12/E47 [ 14 ] and can interact with the tumor suppressor RB1 [ 15 ] . MSX1 expression can revert differentiated myotubes into an undifferentiated state [ 16 ] . REST/NRSF is known to block neural differentiation by binding to and inhibiting the expression of neuronal genes [ 17 18 ] . To what extent these genes are controlled by Wnt signaling in intact animals or in other cell types is not clear yet, but we do note that MSX mutants have phenotypes similar to LEF/TCF mutants [ 19 20 ] .
The TCF family member Elk-1 and C/EBPβ interact in vitro
In the Wnt target gene promoters that are functionally mapped (MSX1, MSX2, ID2, ID3, Follistatin, REST/NRSF, Versican) we invariably found TCF binding sites.
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