Words similar to tcd
Example sentences for: tcd
How can you use “tcd” in a sentence? Here are some example sentences to help you improve your vocabulary:
The study was stopped early by the Data and Safety Monitoring Board due to the finding of a significant reduction in the number of strokes (90% reduction, p < .001) in the transfusion arm (11 strokes in the observation arm vs. one in the transfusion arm) [ 11 ] . Thus, the STOP study established that transfusion was an effective means of primary stroke prevention in children with sickle cell disease at risk for stroke as determined by TCD.
Data from the STOP study showed that ~10% of patients with Hb SS between the ages of 2-16 years are at risk for stroke as determined by Transcranial Doppler (TCD) velocities of 200 cm/sec or greater [ 11 ] . TCD velocity elevation can be due to two factors: reduction of arterial diameter due to stenosis and/or increased volume flow through the artery.
Rejection of the null hypothesis of no three-way association in the table would lead to the conclusion that the proportion with high TCD depends upon the joint effects of the two genes rather than on their separate effects.
Results are presented in table 2. On the assumption that the goal of the study is to identify mutant alleles that occur with increased frequency in patients with high TCD, the table is limited to cases in which p 1 > p 2 . To save space, the table is further limited to entries that just span the range of differences, p 1 - p 2 , that can be detected with 80-90% power for each specified value of p 1 . Based on these power analyses we conclude that we have good power to detect realistic differences in frequencies of alleles that increase risk of cerebrovascular disease and stroke in cases as compared to controls.
The recently funded STOP-II study, to be conducted in 24 centers, will investigate the duration of stroke risk and the feasibility of discontinuing transfusion after 30 months in patients whose TCD velocities have normalized after transfusion.
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