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Example sentences for: tcf-

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Several other HMG-box proteins also play important roles in lymphocyte development [ 17 ] . Mice doubly deficient in lymphocyte enhancement factor-1 (LEF-1) and T cell factor-1 (TCF-1) have a complete block in development of T cells [ 18 19 ] , while deficiency of SRY-box containing protein 4 (SOX-4) in mice results in a lack of pro-B cell expansion and mild perturbation of thymocyte development [ 20 ] . Unlike these HMG-box proteins, however, we find that the HMG-box of TOX is more closely related to the DNA binding domain of sequence-independent HMG-box proteins.