Words similar to tcr
Example sentences for: tcr
How can you use “tcr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus, the observed reduction of tumor burden produced by the combinatorial treatment translated into significant survival advantage, and the effect was dependent on the increased frequency of tumor-antigen specific T cells from the TCR transgenic.
For TCR stimulation, cells for each condition were concentrated into 0.5 ml, warmed to 37°C for 10 minutes and then treated with 10 μg OKT3.
Apart from peptide MHC specificity many other important parameters that describe cellular mechanisms such as enzyme-mediated antigen processing, peptide transport, loading of peptides to MHC molecules and the phenomenon of TCR repertoires have to be identified and incorporated into the prediction framework.
For the current study, we selected samples from six melanoma patients from these trials—four with vaccine-elicited responses (patients 422, 476, 517, and 520) and two with endogenous T cell responses (patients 132 and 461)—for detailed analyses of TCR VB usage, RE for the target peptide, and tumor cytotoxicity.
Our finding that KRC binds to the RSS as well as the κB motif may also provide a link between transcription and recombination in the context of the accessibility model [ 58 59 ] . Enhancer or promoter elements are important for the recombination process in cell lines and animal models [ 60 ] . Similarly, expression of transcription factors, in conjunction with the recombination activating genes, has been shown to induce V(D)J recombination in non-lymphoid tissues by rendering RSS accessible to the recombinase [ 61 ] . The κB motif, first found in the Igκ light chain [ 62 ] , and later in the TCR β2 locus [ 31 ] , has been shown to promote V(D)J recombination by modulating locus accessibility [ 63 ] . In addition to influencing recombination by binding of RSS, KRC binding of the κB motif may modulate accessibility and transcription of target loci.
Loading...