Words similar to tcr

Example sentences for: tcr

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The relatively short kinetics of surface CD4 down-regulation and the delayed CD8 surface disappearance can be interpreted as a PKC-mediated selection signaling in favor of CD8 +CD4 -/α:β-TCR cells that may operate during intrathymic T cell differentiation.
On the other hand, apoptosis was ruled out as a mechanism to explain the differential down-regulation of CD4 and CD8 by PMA and cAMP, on the grounds of two independent observations: (a) After a maximum of 4.0 hr incubation with either PMA or cAMP+ IBMX the cell viability was the same as the untreated controls (usually between 90-95%); (b) Treatment with dexamethasone, which is a known pro-apoptotic molecule did not have any effects on the expression of either CD4 or CD8 (data not shown) and; (c) As demonstrated earlier in the murine system, TCR engagement of CD4 +CD8 +induces positive selection but not apoptosis [ 12 ]
TCR, T cell receptor; MHC, major histocompatibility complex; H-2, murine MHC locus; Tag, SV40 T antigen; RIP, rat insulin promoter; RAG, recombinase activating gene.
The CD4 +CD25 +T cells are functionally normal because the CD4 +CD25 +cells can significantly inhibit the proliferation of the CD4 +CD25 -cells induced by TCR stimulation (Fig.
Consistent with SH-2 interaction, CD5 cytoplasmic tyrosine residues are phosphorylated by p56 lck kinases upon TCR/CD3 ligation and serve as targets for association with proteins containing SH2 domains in both T and B-1a cells [ 12, 21, 22].