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Example sentences for: tdt
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Fine mapping of this region, using nine additional markers, with an average spacing of 0.9 cM confirms the evidence of linkage to 13q32 around markers D13S79-D13S225 [ 15 ] . Association analyses with GASSOC TDT and ASPEX /Sib_tdt showed linkage disequilibrium signals with several markers, including D13S280 which need follow up by typing more markers in the region in a larger sample size [ 15 ] . Meta analysis of whole-genome linkage scans further strengthens the susceptibility locus of BP on chromosome 13q32 [ 13 ] . All these studies clearly point towards further efforts in the identification of susceptibility genes for this disorder.
TdT enzyme and TdT buffer were purchased from Promega (Madison, WI, USA).
ADPRT = adenosine diphosphate ribosyltransferase; cM = centiMorgan; C-TDT = combined S-TDT and TDT; ESRRG = estrogen-related receptor gamma; HLA = human leukocyte antigen; kb = kilobasepairs; LOD = logarithm of odds ratio; MIM = Mendelian Inheritance in Man (database; see [ 1]); PARP = poly ADP ribosyl polymerase; PCR = polymerase chain reaction; PDT = pedigree disequilibrium test; SLE = systemic lupus erythematosus; S-TDT = discordant-sib TDT; TDT = transmission disequilibrium test; T:NT = ratio of transmitted to nontransmitted alleles.
The two-marker haplotypes D1S425-allele 10/D1S2827-allele 11, D1S490-allele 7/D1S227-allele 5, and D1S2616-allele 6/D1S549-allele 12 were significant in the TDT, C-TDT, and PDT.
The alleles from the 11-marker fine map were examined for the presence of transmission disequilibrium using the transmission disequilibrium test (TDT) [ S7] and the discordant sibling TDT (S-TDT) test [ S8].
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