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Example sentences for: tds
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Identifying L1-TDs
We have previously found that nearly 9% of recent L1 insertions in the human genome have TSDs that are consistent with 3' transduction [ 23 ] . That is, the 3' TSD of these L1s with transduction-derived sequence (L1-TDs) is preceded by a poly(A) tail and located up to several hundred nucleotides downstream from the end of the L1 3' UTR [ 35 36 ] . On the other hand, standard L1 insertions have TSDs that follow a poly(A) tail immediately flanking the L1 sequence.
An inordinate number of our putative L1-TDs were within genomic duplications located on the Y chromosome, whereas only two such occurrences were found on the gene-rich chromosome 19 (data not shown).
This can be understood by considering the facts that the human population is highly outbred, and L1 elements are preferentially cis -acting [ 24 27 ] . Progenitor elements for L1-TDs must be transpositionally competent and thus are likely to be relatively young.
In addition, an L1-TD could be the progenitor of subsequent L1-TDs, giving rise to composite transduction events.
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