Words similar to tbp

Example sentences for: tbp

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RNA polymerase II (pol II) transcription factor TFIID comprises the TATA-binding protein (TBP) and a set of TBP-associated factors (TAF II s) [ [ 1 2 3 ] ]. At least 12 TAF II s have been identified in TFIID and cloning of their cDNAs has shown an evolutionary conservation of TAF II s from yeast to mammals [ [ 4 5 6 7 ] ]. TAF II s are not only components of the TFIID complex, but a subset of TAF II s are also found in the SAGA, PCAF, TFTC/STAGA complexes which lack TBP [ [ 8 9 10 11 12 ] ].
We also asked whether the depletion of TBP and TAF II 135 would be observed in nuclear extracts from differentiated F9 cells where the nuclei were extracted with 1.0 M KCl to ensure efficient protein extraction.
In contrast, all three fTAF II 135(805-1083) expressing cell lines and several control lines picked at the same time all showed a normal T-RA response with respect to growth inhibition, differentiated cell morphology, and targeted depletion of TAF II 135 and TBP (Fig.
Thus, while the overall level of TFIID is diminished through the reduction in TBP and TAF II 135, the relative stoichiometry of the remaining TFIID is not significantly altered.
It will therefore be interesting to identify the sequences are required for degradation of TBP and TAF