Words similar to steroidogenic
Example sentences for: steroidogenic
How can you use “steroidogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
i.e. apoptosis), is initiated by prostaglandin F 2α (PGF 2α ) in vivo [ 4 ] . However, this process can only be partially recapitulated in vitro using primary cultures of steroidogenic cells.
While these pathways are activated in luteal steroidogenic cells by diverse cell stressors, including cytokines [ 55 ] , no such detailed studies have been completed to date in the endothelial cell component of the CL.
The microvasculature of the CL is thought to be the first structure to undergo degeneration via apoptosis during luteolysis [ 2 8 ] . In contrast to information available on steroidogenic cells of the CL, a gap exists in our understanding of the factors and their associated signaling pathways that initiate apoptosis in the vascular component of the CL.
These compounds can activate some nuclear receptors including steroidogenic factor 1 [ 44 ] and LXR, which may be partially responsible for their biological activities [ 45 46 ] . Cholesterol oxides are inhibitors of HMG-CoA reductase, the key enzyme of cholesterol biosynthesis pathway [ 47 ] . The ability to bind to an intracellular receptor, oxysterol binding protein, may be responsible for their inhibition of cholesterol biosynthesis [ 48 49 ] . It should be noted that addition of cholesterol does not prevent cholesterol oxide induced cell death, which leads to the suggestion that inhibition of cholesterol synthesis is not the cause of cholesterol oxide induced PCD [ 50 51 ] . The critical events that result in cholesterol oxide induced cytotoxicity remain to be determined.
The pig granulosa cell line PGC-2 was obtained from Bruce Downey (McGill University) and maintained in culture in McCoy's modified 5A medium supplemented with 10% FBS, as described previously in detail [ 19 ] . PGC-2 cells have been well-characterized with respect to steroidogenic capability, cAMP response, and gonadotropin insensitivity [ 19 ] . Here, PGC-2 were seeded at a density of approximately 5 × 10 5cells/ml of serum-containing medium in 24-well tissue culture plates.
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