Words similar to steroidogenic
Example sentences for: steroidogenic
How can you use “steroidogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Alterations in p53 were related to accretions of apoptotic/internucleosomal DNA cleavage sites [ 13 ] , the oxidative DNA stress marker 8-oxoguanine [ 14 ] , the survival protein Bcl-2 [ 15 ] , and base-excision repair polymerase β [ 16 ] . Corpora lutea were evaluated for progesterone and steroidogenic cell and vascular compositions.
Luteal progesterone and tissue areas occupied by blood vessels and large and small steroidogenic cells were similar between groups.
StAR plays a key role in the initial steps of steroidogenesis, because it is required for transport of cholesterol to the inner mitochondrial membrane where CYP11A1 resides and the first reaction in progesterone synthesis occurs [ 45 ] . cAMP is a well known second messenger in FSH- and LH-stimulated progesterone synthesis, and a key effect of the cAMP-dependent protein kinase in GC is transcriptional control of StAR [ 46 47 ] . Estradiol is recognized as a biological amplifier of basal, FSH- and cAMP-stimulated progesterone production in pig GC, with significant synergistic effects distal to the generation of cAMP at one or more steps in cholesterol transport and metabolism [ 48 ] . Our experimental results are thus consistent with 4-AP inhibition of GC progesterone output via drug effects on multiple interacting sites in the steroidogenic pathway.
These compounds can activate some nuclear receptors including steroidogenic factor 1 [ 44 ] and LXR, which may be partially responsible for their biological activities [ 45 46 ] . Cholesterol oxides are inhibitors of HMG-CoA reductase, the key enzyme of cholesterol biosynthesis pathway [ 47 ] . The ability to bind to an intracellular receptor, oxysterol binding protein, may be responsible for their inhibition of cholesterol biosynthesis [ 48 49 ] . It should be noted that addition of cholesterol does not prevent cholesterol oxide induced cell death, which leads to the suggestion that inhibition of cholesterol synthesis is not the cause of cholesterol oxide induced PCD [ 50 51 ] . The critical events that result in cholesterol oxide induced cytotoxicity remain to be determined.
Antibody directed against steroidogenic acute regulatory protein (StAR) was a gift from D.B.
Loading...