Words similar to sterolin-
Example sentences for: sterolin-
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In comparison, extensive studies on evaluation of high phytosterol diets in SD rats (non-sitosterolemic) have consistently shown to be safe without any adverse consequences [ 36 37 38 39 40 41 42 ] . These intriguing differences between SHRSP and SD rats may now be explained, at least in part, by presence of the Gly583Cys missense mutation in sterolin-1.
Such lines will be useful in demonstrating that the variant sterolin-1 protein is responsible for causing sitosterolemia, but will allow comparisons between animals that are hypertensive and those that are hypertensive and sitosterolemic.
Abcg8 . However, only one non-synonymous nucleotide change, G1754T, resulting in a conservative cysteine substitution for glycine at amino acid 583 (Gly583Cys) in sterolin-1 was identified (Fig.
However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
A reliable antibody to sterolin-1 was available only and was used to probe liver microsomal lysates from Sprague Dawley, SHR and Wistar rats (Fig.
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