Words similar to sterolin-

Example sentences for: sterolin-

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Such lines will be useful in demonstrating that the variant sterolin-1 protein is responsible for causing sitosterolemia, but will allow comparisons between animals that are hypertensive and those that are hypertensive and sitosterolemic.
The predicted 6 trans-membrane domain model of sterolin-1 indicates that the Gly583Cys missense mutation is located within the third extracellular loop (residues 554-620), in a conserved region (Fig 5C) and is adjacent to two potential N -glycosylation sites (residues 585 and 594).
Finally, both the sterolin-1 and sterolin-2 are cysteine-rich proteins (16 cysteines in sterolin 1 and 14 in sterolin 2), five of these cyteines in sterolin-1 are present in the extracellular loop containing the mutation.
However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
Evidence that sterolin-1 and sterolin-2 may heterodimerize has now been presented, based upon in vitro analyses [ 13 ] . However, our preliminary analyses of immunohistochemistry, using an antibody to sterolin-1 suggests that the pattern of expression in the liver and intestine is similar for both SD as well as WKY or SHR rats (Fig.