Words similar to sterol
Example sentences for: sterol
How can you use “sterol” in a sentence? Here are some example sentences to help you improve your vocabulary:
In humans and animals, cholesterol is the sterol that is synthesised, absorbed and utilised, whereas plants do not synthesise cholesterol, but use molecules that are similar, such as sitosterol, campesterol and stigmasterol.
However, a literature search revealed that a few strains of rats, studied primarily for investigation of hypertension and stroke, have been reported to be sitosterolemic as well [ 15 16 ] . We hypothesised that these rat strains may be mutated in either Abcg5 or Abcg8 . Tissue (and plasma) plant sterol levels in the Wistar Kyoto (WKY) rat, the spontaneously hypertensive rat (SHR) and the stroke-prone spontaneously hypertensive rat (SHRSP) were significantly higher than in Wistar and WKA rats fed either a regular chow diet or diets that have higher plant sterols and these were correlated with increased death, or red cell hemolysis etc. [ 15 16 17 18 19 20 21 22 ] . Dietary sterol absorption rates were increased, with a decrease in sterol excretion [ 16 ] , characteristics similar to that observed in sitosterolemic patients.
SREBPs are critically important basic helix-loop helix (bHLH) transcription factors activated in response to variations in intracellular cholesterol levels that induce transcription of genes with sterol regulatory element (SRE) and E-box containing promoters.
A more relevant question raised in this study is whether the plant sterol accumulation in hypertensive rat strains has significance in the pathophysiology of hypertension.
Interestingly, a similar whole-body accumulation of plant sterols, less severe than in human sitosterolemia, has been reported recently in SHR, SHRSP and WKY rats, but not in the other genetically related rat strains, such as SD, Wistar and WKA rats [ 16 ] . These rats exhibit defects at two levels: increased absorption of sterols (plant and animal) at the intestinal level and decreased excretion of sterols into bile [ 16 ] . The higher sterol absorption in the intestine and the lower biliary excretion of plant sterols in these rat strains led us to hypothesise that Abcg5 or Abcg8 gene mutations may be responsible for the sitosterolemia observed in these hypertensive rats.
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